Epigenetic Regulation in Liver Metabolic Homeostasis and Disease
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 89
Special Issue Editors
Interests: liver metabolism; RNA biology; epigenetic modification; cancer biology; genetics; bioinformatics
Special Issue Information
Dear Colleagues,
The liver is a key organ that governs metabolic homeostasis and supports immunity, digestion, detoxification, and vitamin storage. Structurally and functionally heterogeneous, the liver comprises various cell types, including epithelial cells (hepatocytes and cholangiocytes), Kupffer cells, circulating monocytes, mesenchymal cells (such as hepatic stellate cells), and sinusoidal endothelial cells. Metabolic disorders affecting the liver can lead to chronic liver diseases such as fatty liver, cirrhosis, and liver cancer, whose underlying mechanisms are still not fully understood. Recent studies have highlighted the significance of epigenetic regulation in both liver metabolism and disease. Epigenetic modulation can occur at various levels, with DNA methylation, histone modification, and non-coding RNA (ncRNA) as its three major, extensively researched mechanisms. Additionally, the discovery of RNA modification has added a new layer of epigenetic regulation in gene expression. We also know that epigenetic changes can be influenced by several factors, including age, diet, smoking, stress, and disease state. Although advancements in technologies have significantly improved our understanding of epigenetic regulation in the liver, substantial gaps remain regarding its impact on liver disease. To address this, this Special Issue welcomes original research articles and reviews focused on epigenetic regulation in liver metabolic homeostasis and disease.
Dr. Chengfei Jiang
Dr. Zhe Li
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- liver metabolism
- epigenetic regulation
- RNA modification
- metabolic disorder
- non-coding RNA
- liver disease
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
