Human Pluripotent Stem Cells for Therapy

Dear Colleagues,

Recent success in demonstrating the ability of naïve human pluripotent stem cells to survive and re-colonize robustly (after dissociating into single cells), represents a new milestone in stem cell research. In the meantime, the CRISPR/Cas9 nuclease, a newly emerged genomic editing tool that exhibits incomparable simplicity and efficiency when applied to multiple species and cell types, has pushed the boundaries of investigation and utility, with respect to human pluripotent stem cells. These advances are anticipated to have a great impact on both biomedical research and its industry. Also, more interesting discoveries can be expected in the near future.

In this Special Issue of Biomedicines, we invite front-line researchers to submit original research papers and review articles that explore the potential of these new advances to promote the therapeutic applications of human ES cells and iPS cells. Topics may include, but are not limited to:

• Different methods used to establish naïve human pluripotent stem cells
• Chemicals used for stem cell fate decision and reprogramming
• Gene targeting in human pluripotent stem cells
• New CRISPR/Cas9 nuclease applications

Dr. Bo Feng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• human embryonic stem cells
• induced pluripotent stem cells
• ground stage of mouse embryonic stem cells
• naïve state of human embryonic stem cells
• single cell dissociation of human embryonic stem cells
• crispr/cas9
• talen
• engineered nuclease
• engineered transcription factors
• gene targeting