Tumor Microenvironment, Immunity and Tumor Immune Escape Mechanisms: Emerging Treatment Strategies for Fighting Cancer
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 568
Special Issue Editor
Interests: tumor heterogeneity; hypoxia; immune evasion; tumor microenvironment; resistance; immunotherapy; biomarkers, NK cells; CTL; cellular plasticity; EMT; prostate cancer; urology; lung cancer; renal cancer; melanoma
Special Issue Information
Dear Colleagues,
Evading the immune system is one of the hallmarks of cancer. Tumors represent a complex ecosystem infiltrated by immune cell populations and diverse stromal cell types evolving in a special physicochemical milieu and various stress conditions. Tumors escape anti-tumor immunity through cell-intrinsic routes and the assembly of an immunosuppressive tumor microenvironment (TME). Recent cancer immunotherapies have revolutionized the management of many patients with aggressive cancers. This also reveals the potential of boosting pre-existing immunological features in some patients. Nonetheless, a significant proportion of patients remain refractory or rapidly relapse, and the factors involved in resistant and relapsing diseases are still poorly understood. This Special Issue will focus on novel mechanisms involving the TME, malignant cells and points of crosstalk that might be key determinants in immune escape and immunotherapeutic resistance. It will also highlight novel methods and compounds developed targeting the TME and its metabolism to optimize immunotherapy-based interventions and widen the therapeutic options for patients.
Dr. Stephane Terry
Guest Editor
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Keywords
- tumor microenvironment
- tumor heterogeneity
- tumor immunity
- tumor resistance
- immune evasion
- immunotherapy
- hypoxia
- targeted therapy
- immuno-oncology
- combination therapy
- drug development
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