The Wnt Signaling Pathway in Cancers
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".
Deadline for manuscript submissions: closed (31 January 2022) | Viewed by 279
Special Issue Editor
Interests: leukemia; drug resistance; microenvironment; integrin; acute lymphoblastic leukemia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue focuses on the Wnt Signaling Pathway in Cancers. Wnt signaling has been of considerable interest in both stem cell and cancer biology, both in the homeostatic maintenance of tissues and organs through their respective somatic stem cells (SSCs) and in cancer stem cells (CSCs). The functions include cellular processes such as self-renewal capacity, proliferation, differentiation potential, and maintenance of the stem cell niche. The role of aberrant wnt signaling in cancer stem cells (CSCs) has been demonstrated in a wide variety of cancers, including brain tumors, melanoma, breast, liver, pancreatic, and colon cancer, but also hematological malignancies. Wnt signaling has been shown to be involved in the initiation of disease, therapeutic resistance, and ultimately, disease relapse. One key focus in cancer research has been to develop therapies to safely eliminate CSCs. The precise understanding of the regulation of wnt signaling, the crosstalk of wnt signaling with other signaling pathways, and downstream targets are key for successful translational efforts, which will be the focus of this Special Issue. Original investigations as well as concise review manuscripts from experts in the relevant research fields will be considered for publication.
Prof. Dr. Yong-mi Kim
Guest Editor
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Keywords
- wnt
- cancer
- drug resistance
- therapy
- microenvironment
- self-renewal
- differentiation
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