Advances in Bio-Integrated Neural Interfaces: Materials, Devices, and Translational Applications

A special issue of Biomimetics (ISSN 2313-7673). This special issue belongs to the section "Biomimetic Design, Constructions and Devices".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 1122

Special Issue Editors


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Guest Editor
Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA
Interests: biomedical device; soft electronics; soft robotics; nano/micro manufacturing; nanomaterials

E-Mail Website
Guest Editor
Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, USA
Interests: biomedical device; neurotechnology; neural interface systems; nano/micro manufacturing; nanomaterials; soft electronics

E-Mail Website
Guest Editor
1. Department of Mechanical and Aeriospace Engineering, University of California San Diego, La Jolla, CA, USA
2. Department of Biomedical and Instruments Engineering, Abdullah Al Salem University, Khaldiya, Kuwait
Interests: soft electronics; nanomaterials and organic materials; haptics; neurotechnology

Special Issue Information

Dear Colleagues,

Recent advances in biomimetic and bio-integrated electronics are redefining the field of neural engineering by enabling seamless communication between the brain and external systems. Breakthroughs in biomimetic materials, soft and stretchable device architectures, and nature-inspired fabrication strategies that replicate the mechanical and physiological properties of neural tissue have driven the development of next-generation neural interfaces. Flexible depth probes, high-density electrocorticography (ECoG) arrays, and wireless brain–computer interfaces (BCIs) are now opening new opportunities for precise neural recording, stimulation, and closed-loop modulation with improved biocompatibility and long-term stability.

This Special Issue will showcase cutting-edge research and reviews on the design, fabrication, and translational application of bio-integrated neural interfaces and technologies. Topics of interest include novel materials for neural interfaces, soft, flexible, and minimally invasive probes, wireless and closed-loop BCI platforms, AI-driven neural signal processing, and nature-inspired design strategies that enhance device functionality and long-term stability.

By bringing together contributions from materials science, electronics, neuroscience, and biomedical engineering, this issue aims to provide a comprehensive overview of emerging directions in neural interface research. We particularly encourage submissions that bridge fundamental studies and translational pathways, with the goal of accelerating the clinical and societal impact of next-generation neurotechnologies for healthcare, rehabilitation, and brain–machine integration.

Dr. Hyeonseok Kim
Dr. Jihwan Lee
Dr. Abdulhameed Abdal
Guest Editors

Manuscript Submission Information

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Keywords

  • brain–computer interfaces (BCIs)
  • bio-integrated electronics
  • neural interfaces
  • flexible and stretchable devices
  • depth probes
  • electrocorticography (ECoG)
  • neural recording and stimulation
  • translational neurotechnology
  • wireless neural systems
  • biomimetic design

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Published Papers (1 paper)

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Research

20 pages, 4080 KB  
Article
Bio-Compatibility Analysis of Newly Developed Plug and Cuff Electrodes for Future Neuronal Interface Applications
by Eleni Zingkou, Georgios Pampalakis, Asimina Kolianou, Nafsika Rossopoulou, Aikaterini Skiada, Lydia Galouni, Patryk Śniarowski, Longina Madej-Kiełbik, Georgia Sotiropoulou, Karolina Gzyra-Jagieła, Theodora Katsila, Carmen Moldovan, Marian Ion, Octavian Narcis Ionescu, Eduard Franti, David Dragomir, Gerd Siekmeyer and Patrick Grotemeyer
Biomimetics 2026, 11(2), 147; https://doi.org/10.3390/biomimetics11020147 - 16 Feb 2026
Viewed by 796
Abstract
The NerveRepack project is a European initiative that aims to develop biomimetic exoskeletons/exoprostheses for amputated or paralyzed leg patients that will receive and transmit signals to enable movements and sensations for the patient. To implement the project, it is fundamental to develop implantable [...] Read more.
The NerveRepack project is a European initiative that aims to develop biomimetic exoskeletons/exoprostheses for amputated or paralyzed leg patients that will receive and transmit signals to enable movements and sensations for the patient. To implement the project, it is fundamental to develop implantable neuronal electrodes that will allow bidirectional signaling between the sensors placed on the exoskeletons/exoprostheses and the nervous system. In this direction, two electrodes, plug and cuff, have been designed as integral parts of the final implantable device. The electrodes should comply with strict regulations to ensure their safe implantation in patients. The purpose of this study was to support the compliance of the implant platforms of certain key components with the ISO and ASTM standards that would be required for clinical applications. We have used an indirect method to assess the biocompatibility of the developed electrodes against neuronal cells, fibroblasts, and keratinocytes. Also, we assessed hemocompatibility, i.e., the potential of implantable electrodes to induce hemolysis or complement activation. Finally, the mutagenic/genotoxic potential was tested against the internationally recommended CHO cells. Both representative plug and cuff electrode components were found non-cytotoxic, non-mutagenic, and unable to induce hemolysis. Therefore, from the point of early evaluation of in vitro material and process biocompatibility, the selected implant platforms for the electrodes could be implanted in preclinical models to delineate their potential in vivo applications as neuronal interface with the biomimetic exoskeleton/exoprostheses. Full article
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