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Biophysica
Special Issues
Biomedical Optics: 3rd Edition
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Biomedical Optics: 3rd Edition

A special issue of Biophysica (ISSN 2673-4125).

Deadline for manuscript submissions: 31 October 2025 | Viewed by 988

Special Issue Editor

Prof. Dr. Herbert Schneckenburger

E-Mail Website
Guest Editor
Institute of Applied Research, Aalen University, Beethovenstr. 1, 73430 Aalen, Germany
Interests: biomedical optics; laser; microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical optics play an increasing role in the diagnosis and treatment of patients, as well as in advanced studies of biology. Novel methods of 3D microscopy based on various kinds of illumination patterns (wide field, focused laser beam, structured, or light sheet) are adapted for investigations of 3-dimensional cell cultures, tissues or whole organs. In addition, laser-assisted micromanipulation, e.g., optical tweezers or optoporation techniques, have been revealed as helpful tools for the diagnosis or treatment of single cells. In vitro diagnostics often requires methods of (super-resolution) microscopy, hyperspectral imaging or fluorescence lifetime imaging as well as the application of opto-acoustic methods, high-content reader systems or optical biosensors. Deconvolution, automated image processing and machine learning have become valuable tools for the evaluation of large data sets. Contributions on all these and related techniques, as well as their applications in various fields of biology, are welcome in this Special Issue.

Prof. Dr. Herbert Schneckenburger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biophysica is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical optics
  • 3D microscopy
  • laser-assisted micromanipulation
  • optical biosensors

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Published Papers (2 papers)

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Research

14 pages, 1386 KB  
Article
Probing the Interaction Between Icariin and Proteinase K: A Combined Spectroscopic and Molecular Modeling Study
by Zhongbao Han, Huizi Zheng, Yimeng Qi, Dilshadbek T. Usmanov, Liyan Liu and Zhan Yu
Biophysica 2025, 5(3), 32; https://doi.org/10.3390/biophysica5030032 - 28 Jul 2025
Viewed by 356
Abstract
Icariin (ICA) is widely recognized for its health benefits. In this work, we examined the intermolecular interactions between ICA and proteinase K (PK) via multi-spectroscopic techniques and molecular simulations. The experimental findings revealed that ICA quenched the fluorescence emission of PK by forming [...] Read more.
Icariin (ICA) is widely recognized for its health benefits. In this work, we examined the intermolecular interactions between ICA and proteinase K (PK) via multi-spectroscopic techniques and molecular simulations. The experimental findings revealed that ICA quenched the fluorescence emission of PK by forming a noncovalent complex. Both hydrogen bonding and van der Waals interactions are essential for the complex’s formation. Then Förster resonance energy transfer (FRET), competitive experiments, and synchronous fluorescence spectroscopy were adopted to verify the formation of the complex. Molecular docking studies demonstrated that ICA could spontaneously bind to PK by hydrogen bonding and hydrophobic interactions, which is consistent with the spectroscopic results. The PK-ICA complex’s dynamic stability was evaluated using a 50 ns molecular dynamics (MD) simulation. The simulation results revealed no significant structural deformation or positional changes throughout the entire simulation period. The complex appears to be rather stable, as seen by the average root-mean-square deviation (RMSD) fluctuations for the host protein in the PK-ICA complex of 1.08 Å and 3.09 Å. These outcomes of molecular simulations suggest that ICA interacts spontaneously and tightly with PK, consistent with the spectroscopic findings. The approach employed in this research presents a pragmatic and advantageous method for examining protein–ligand interactions, as evidenced by the concordance between empirical and theoretical findings. Full article
(This article belongs to the Special Issue Biomedical Optics: 3rd Edition)
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16 pages, 8409 KB  
Article
Imaging of Laser-Induced Thermal Convection and Conduction in Artificial Vitreous Humor
by Jack Pelzel, Reese Anderson, Darin J. Ulness and Krys Strand
Biophysica 2025, 5(3), 31; https://doi.org/10.3390/biophysica5030031 - 27 Jul 2025
Viewed by 376
Abstract
This study extends the application of photothermal spectroscopy to explore heat transfer dynamics in biological fluids, focusing on the examination of artificial vitreous humor (VH) models of human VH and an endogenous sample of cervine (deer) VH. The research integrates previously established methods [...] Read more.
This study extends the application of photothermal spectroscopy to explore heat transfer dynamics in biological fluids, focusing on the examination of artificial vitreous humor (VH) models of human VH and an endogenous sample of cervine (deer) VH. The research integrates previously established methods for analyzing thermal lensing through photothermal deflection. By visualizing convective and conductive heat transfer processes in the artificial components of human VH, one gains insights into the dynamic behavior of heat transfer in the VH. Relevance extends to clinical cases where pathology requires replacement of endogenous VH with an artificial VH substitute. Several VH substitutes identified in the literature were chosen for this study based on their physical properties and relative abundance in the VH. Individual component fluids, and mixtures of these components, were analyzed at various concentrations based on their physiological concentration ranges in the human VH as they varied with age, sex, and certain disease states. By way of comparison to endogenous biological VH, a sample of VH obtained from a female white-tailed deer eye was analyzed, enhancing the understanding of heat transfer in artificial components of the VH compared to endogenous VH. There is a vast array of ophthalmological procedures that utilize an external heat source interacting with endogenous or artificial VH. The data found in this study will progress the understanding of heat transfer within artificial VH components in comparison to endogenous VH and contribute to the advancement of certain ophthalmological procedures. Full article
(This article belongs to the Special Issue Biomedical Optics: 3rd Edition)
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