Progress in Electrochemiluminescence Biosensors

Dear Colleagues,

Electrochemiluminescence (ECL), also referred to as electrogenerated chemiluminescence, is a technique extensively employed in the emission of light from electrochemically excited ECL emitters via efficient electron transfer. In recent years, ECL has gained recognition in characterization, sensing, imaging, and devices due to its high sensitivity, low background, and wide dynamic range, benefiting from the combination of electrochemistry and chemiluminescence. During ECL, the excited state produced by electron transfer relaxes, accompanied by luminescence to the ground state.

In comparison with other optical-based analytical methods, the ECL process offers some advantages: Firstly, the emission of light in ECL does not require an external source of light, eliminating background noise from the sample’s auto fluorescence or scattered light. Secondly, the emission of light in ECL can be controlled by the potential applied at an electrode. In addition, the ECL technique offers precise control over the emission position, since the emission in ECL is close to the electrode surface, which is advantageous for selectivity, sensitivity, imaging analysis, and the detection of multianalytes. Thirdly, some ECL reactants can be electrochemically regenerated at the electrode. This enhances the sensitivity of the technique, reduces the use of reactants, and simplifies the instrument. Consequently, ECL is an extremely effective analytical tool in the realm of sensing research, as well as in commercial and clinical applications.

This Special Issue welcomes the submission of both original research articles and comprehensive reviews that explore the latest advancements in the field of ECL biosensors. These contributions may encompass, but are not limited to, investigations into luminophores, the underlying mechanisms, co-reactants, co-reactant accelerators, electrode surface modifications, signal amplification tactics, potential-resolved strategies, readout methodologies, imaging techniques, and diverse applications. Of particular interest is the integration of ECL in biosensor fabrication, and the challenges and applicative potential associated with this technology. We look forward to receiving insightful and groundbreaking research in order to enrich this Special Issue.

Prof. Dr. Zonghua Wang
Dr. Feifei Zhang
Dr. Huixin Zhang
Guest Editors

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• electrochemiluminescence
• biosensors
• nanomaterials
• luminophores
• signal enhancement
• co-reactant accelerator
• electrocatalytic activity
• application