Natural Products and Their Derivatives in Immunity

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 25 November 2024 | Viewed by 823

Special Issue Editor


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Guest Editor
Department of Pharmacy Practice & Science, School of Pharmacy, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE 68198, USA
Interests: natural product; flavonoids; phytochemistry; pharmacology; pharmacokinetics of phytoestrogens

Special Issue Information

Dear Colleagues,

In ancient times, natural products are endogenous chemical components which include compounds derived from plants, fungi, microorganisms and animals, etc., have been used in traditional medicine systems and are now gaining recognition for their immunomodulatory properties. The immune system is a remarkable defense mechanism that safeguards our bodies from a multitude of pathogens and diseases. Immunity usually refers to the body's ability to resist the invasion of pathogenic microorganisms and various diseases, protecting us from viruses and other causative agents. While modern medicine has made significant strides in developing vaccines and pharmaceuticals, there is a growing interest in harnessing the potential of natural products and their derivatives to enhance immunity. The immune efficacy of natural products has received more and more attention especially during the recent epidemic of COVID-19. In addition, natural products also play an important role in cancer immunity research. Scientists are increasingly exploring natural product derivatives, such as isolated compounds and synthetic analogs, to develop targeted therapies and vaccines. Thus, the study of natural products and their derivatives in the context of immunity has gained substantial attention in recent years due to the growing interest in holistic and alternative approaches to health and well-being.

The aim of this Special Issue is to present the promising avenue for enhancing immunity and preventing diseases using natural product, and the understanding of immunization through natural products and their derivatives. Therefore, we are pleased to invite you to submit an article or review focusing on the role of natural products in immunity. Potential topics can include, but are not limited to, the following:

  1.  The exploration of natural products and their derivatives in the context of immunity to offer promising avenues for enhancing immune responses and preventing diseases;
  2.  The mechanism of immune protection of natural products for various diseases, such as cancer, COVID-19, etc.;
  3.  Cell-based experiments that can reveal the molecular mechanism of immunity;
  4.  The synergistic effect of various natural products on immunity.

Dr. Mamunur Rashid
Guest Editor

Manuscript Submission Information

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Keywords

  • natural products
  • immunomodulatory
  • diseases
  • molecular mechanism of immunity

Published Papers (1 paper)

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Research

19 pages, 6160 KiB  
Article
Stable Dietary Ora-Curcumin Formulation Protects from Experimental Colitis and Colorectal Cancer
by Chaitanya K. Valiveti, Balawant Kumar, Anuj D. Singh, Sham K. Biradar, Rizwan Ahmad, Amar B. Singh and Hemachand Tummala
Cells 2024, 13(11), 957; https://doi.org/10.3390/cells13110957 - 1 Jun 2024
Viewed by 545
Abstract
Inflammatory bowel disease (IBD) is a chronic gut disorder that also elevates the risk of colorectal cancer (CRC). The global incidence and severity of IBD are rising, yet existing therapies often lead to severe side effects. Curcumin offers potent anti-inflammatory and chemotherapeutic properties. [...] Read more.
Inflammatory bowel disease (IBD) is a chronic gut disorder that also elevates the risk of colorectal cancer (CRC). The global incidence and severity of IBD are rising, yet existing therapies often lead to severe side effects. Curcumin offers potent anti-inflammatory and chemotherapeutic properties. However, its clinical translation is hindered by rapid metabolism, as well as poor water solubility and stability, which limits its bioavailability. To address these challenges, we developed OC-S, a water-soluble and colon-targeted curcumin formulation that protects against colitis in mice. The current study advances OC-S as a dietary supplement by establishing its stability and compatibility with various commercial dietary products. Further, OC-S exhibited specific binding to inflamed colon tissue, potentially aiding in targeted drug retention at the inflammation site in colitis with diarrhea symptoms. We further investigated its efficacy in vivo and in vitro using a murine model of colitis and tumoroids from APCmin mice. OC-S significantly reduced colitis severity and pro-inflammatory cytokine expression compared with curcumin, even at very low doses (5 mg/kg/day). It also demonstrated higher anti-proliferative activity in CRC cells and colon cancer tumoroids vs. curcumin. Overall, this study demonstrated that OC-S effectively targets and retains water-soluble curcumin at the inflamed colon sites, while showing promise in addressing both colitis and colorectal cancer, which potentially paves the way for OC-S to advance into clinical development as a dietary product for both IBD and CRC. Full article
(This article belongs to the Special Issue Natural Products and Their Derivatives in Immunity)
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