Cellular and Molecular Mechanisms in Bone and Cartilage Damage and Regeneration
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 284
Special Issue Editor
Interests: cell therapy; bone union; cartilage regeneration; osteonecrosis
Special Issue Information
Dear Colleagues,
Bones and cartilage, the two most important parts of the musculoskeletal system, provide mobility and maintain the body’s posture. Bone and cartilage damage can have a highly deleterious impact on life and society; therefore, understanding the mechanisms of bone and cartilage regeneration is important. However, questions remain regarding the precise mechanisms of bone formation, how the different molecular processes interact, and the real identity of regenerative cells.
In this Special Issue, we invite researchers and industry experts to submit their original research articles and reviews related to the following topics and keywords:
Bone Morphogenic Proteins (BMPs): The role of BMPs in bone and cartilage regeneration; BMP signaling pathways and their implications in orthopedic therapies; and innovative uses of BMPs in reconstructive surgery.
Bone Union with Cell Therapy: Advances in stem cell therapies for fracture non-union; mechanisms and applications of mesenchymal stem cells (MSCs) in bone healing; comparative studies on bone marrow-derived MSCs versus expanded MSCs; and the role of endothelial progenitor cells (EPCs) in bone regeneration.
Cartilage Regeneration: novel cell-based therapies for cartilage repair; functional of collagen/PLA scaffolds in cartilage regeneration; and BMPs in regulating inflammation and promoting osteogenesis at injured growth plates.
Regeneration and Revascularization of Bone Osteonecrosis: Evaluation of bone turnover markers in MSC-regenerative approaches for osteonecrosis; research studies and reviews in bone regeneration for osteonecrosis patients; and evaluation of osteonecrosis regeneration with MRI and histology, and arteriography.
Cartilage Biomarkers: The identification and validation of new cartilage biomarkers; biomarkers in monitoring the progress of cartilage regeneration therapies; and the role of biochemical markers in the diagnosis and treatment of cartilage damage.
Diaphyseal Regeneration with Callostasis: Techniques and outcomes of callostasis in diaphyseal bone regeneration; the use of BMPs and cell-based therapies in enhancing callostasis; and research studies and reviews on the SECCS system and other scaffold-based therapies.
Union with the Membrane Technique: Advances in the membrane technique for guided bone regeneration; mechanisms and applications of barrier membranes in bone healing; and combination therapies involving BMPs and membranes for optimal bone regeneration.
Submissions should provide novel insights, comprehensive reviews, or significant advancements in the field of bone and cartilage damage and regeneration. We hope that a better understanding of the underlying mechanisms can facilitate the development of new strategies for improving bone and cartilage regeneration.
Prof. Dr. Philippe Hernigou
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bone morphogenic proteins (BMPs)
- bone union with cell therapy
- advances in stem cell therapies for fracture non-union and cartilage regeneration
- novel cell-based therapies for cartilage repair
- functional of collagen/PLA scaffolds in cartilage regeneration
- regeneration and revascularization of bone osteonecrosis
- evaluation of osteonecrosis regeneration with MRI and histology, and arteriography
- identification and validation of new cartilage biomarkers
- diaphyseal regeneration with callostasis
- union with the membrane technique
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Comparison of fresh and frozen bone marrow aspirate concentrate cells (BMAC) derived MSCs for in vitro multipotent differentiation and cartilage regeneration in rat OA model
Authors: Xueqin Gao
Affiliation: Steadman Philippon Research Institute (Fort Collins Lab), USA
