Melanoma and Non-melanoma Skin Cancer: Cellular Mechanisms, Immunity and Therapeutics

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 1038

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Guest Editor
Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
Interests: dermal stem cells; skin immunity; ABC transporters; ABCB5; melanoma
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Special Issue Information

Dear Colleagues,

Despite major advances in gene- and immune-targeted therapies, melanoma and non-melanoma skin cancers, once metastasized, remain largely refractory to cures. However, the advent of single-cell omics technologies for cancer characterization, including whole-genome mutational analyses, RNA sequencing, and epigenetic analyses, has recently opened up unprecedented opportunities for the discovery of novel targetable molecular cancer pathways, and hence the development of novel strategies for tumor eradication. This Special Issue aims to present cutting-edge research in the fields of melanoma and non-melanoma skin cancer biology, including the molecular and cellular mechanisms of cancer initiation, immune evasion, cancer plasticity, and metastasis. Moreover, manuscript submissions presenting novel insights into skin cancer therapeutic resistance or exploring potential skin cancer therapeutic approaches are encouraged.

We cordially invite you to contribute your original research to this exciting Special Issue of Cells.

Dr. Markus Frank
Guest Editor

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Keywords

  • melanoma
  • squamous cell carcinoma
  • Merkel cell carcinoma
  • tumorigenicity
  • metastasis
  • therapeutic targets

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Published Papers (1 paper)

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Research

25 pages, 21026 KiB  
Article
Molecular Profiling and the Interaction of Somatic Mutations with Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) in a Population Exposed to Arsenic
by Farzana Jasmine, Maria Argos, Yuliia Khamkevych, Tariqul Islam, Muhammad Rakibuz-Zaman, Mohammad Shahriar, Christopher R. Shea, Habibul Ahsan and Muhammad G. Kibriya
Cells 2024, 13(12), 1056; https://doi.org/10.3390/cells13121056 - 18 Jun 2024
Viewed by 712
Abstract
Exposure to inorganic arsenic (As) is recognized as a risk factor for non-melanoma skin cancer (NMSC). We followed up with 7000 adults for 6 years who were exposed to As. During follow-up, 2.2% of the males and 1.3% of the females developed basal [...] Read more.
Exposure to inorganic arsenic (As) is recognized as a risk factor for non-melanoma skin cancer (NMSC). We followed up with 7000 adults for 6 years who were exposed to As. During follow-up, 2.2% of the males and 1.3% of the females developed basal cell carcinoma (BCC), while 0.4% of the male and 0.2% of the female participants developed squamous cell carcinoma (SCC). Using a panel of more than 400 cancer-related genes, we detected somatic mutations (SMs) in the first 32 NMSC samples (BCC = 26 and SCC = 6) by comparing paired (tissue–blood) samples from the same individual and then comparing them to the SM in healthy skin tissue from 16 participants. We identified (a) a list of NMSC-associated SMs, (b) SMs present in both NMSC and healthy skin, and (c) SMs found only in healthy skin. We also demonstrate that the presence of non-synonymous SMs in the top mutated genes (like PTCH1, NOTCH1, SYNE1, PKHD1 in BCC and TP53 in SCC) significantly affects the magnitude of differential expressions of major genes and gene pathways (basal cell carcinoma pathways, NOTCH signaling, IL-17 signaling, p53 signaling, Wnt signaling pathway). These findings may help select groups of patients for targeted therapy, like hedgehog signaling inhibitors, IL17 inhibitors, etc., in the future. Full article
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