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Cells
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LncRNAs: Biofunctions, Cellular Targets, and Applications
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LncRNAs: Biofunctions, Cellular Targets, and Applications

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 3763

Special Issue Editors

Prof. Dr. Jian-Ying Wang

E-Mail Website
Guest Editor
Department of Surgery, University of Maryland Baltimore School of Medicine, Baltimore, MD, USA
Interests: post-transcriptional regulation; long-noncoding RNAs; RNA-binding proteins; gut mucosal renewal/adaptation; gut barrier function; injury and repair
Dr. Xiao-Di Tan

E-Mail Website
Guest Editor
Department of Pediatrics, University of Illinois College of Medicine at Chicago, Chicago, IL, USA
Interests: epithelial biology; noncoding RNAs; mucosal inflammation and repair

Special Issue Information

Dear Colleagues,

This Special Issue, entitled “LncRNAs: Biofunctions, Cellular Targets, and Applications”, is focused on the elucidation of the biopathological functions of lncRNAs using any chemical, biochemical, biophysical, computational, experimental, or imaging technique in in vitro, ex vivo, and in vivo systems; the study of lncRNA interactions with RNAs and proteins; and the current understanding of their potential clinical applications. Contributions on these topics are welcome, including original research articles and reviews.

Prof. Dr. Jian-Ying Wang
Dr. Xiao-Di Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • post-transcriptional control
  • RNA/RNA interactions
  • functions of lncRNAs

Published Papers (2 papers)

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Research

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16 pages, 2743 KiB  
Article
Exosc9 Initiates SUMO-Dependent lncRNA TERRA Degradation to Impact Telomeric Integrity in Endocrine Therapy Insensitive Hormone Receptor-Positive Breast Cancer
by Maram Quttina, Kacie D. Waiters, Ashfia Fatima Khan, Samaneh Karami, Anthony S. Peidl, Mariam Funmi Babajide, Justus Pennington, Fatima A. Merchant and Tasneem Bawa-Khalfe
Cells 2023, 12(20), 2495; https://doi.org/10.3390/cells12202495 - 20 Oct 2023
Cited by 1 | Viewed by 1892
Abstract
Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation. It is important to delineate the regulatory control of lncRNA degradation, particularly [...] Read more.
Long, noncoding RNAs (lncRNAs) are indispensable for normal cell physiology and, consequently, are tightly regulated in human cells. Yet, unlike mRNA, substantially less is known about the mechanisms for lncRNA degradation. It is important to delineate the regulatory control of lncRNA degradation, particularly for lncRNA telomeric repeat-containing RNA (TERRA), as the TERRA-telomere R-loops dictate cell cycle progression and genomic stability. We now report that the exosome complex component Exosc9 degrades lncRNA TERRA in human mammary epithelial cells. Heterochromatin protein 1 alpha (HP1α) recruits Exosc9 to the telomeres; specifically, the SUMO-modified form of HP1α supports interaction with Exosc9 and, as previously reported, lncRNA TERRA. The telomeric enrichment of Exosc9 is cell cycle-dependent and consistent with the loss of telomeric TERRA in the S/G2 phase. Elevated Exosc9 is frequently observed and drives the growth of endocrine therapy-resistant (ET-R) HR+ breast cancer (BCa) cells. Specifically, the knockdown of Exosc9 inversely impacts telomeric R-loops and the integrity of the chromosome ends of ET-R cells. Consistently, Exosc9 levels dictate DNA damage and the sensitivity of ET-R BCa cells to PARP inhibitors. In this regard, Exosc9 may serve as a promising biomarker for predicting the response to PARP inhibitors as a targeted monotherapy for ET-R HR+ BCa. Full article
(This article belongs to the Special Issue LncRNAs: Biofunctions, Cellular Targets, and Applications)
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Review

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18 pages, 1130 KiB  
Review
The Impact of Long Noncoding RNAs in Tissue Regeneration and Senescence
by Júlia Tavares e Silva, João Pessoa, Sandrina Nóbrega-Pereira and Bruno Bernardes de Jesus
Cells 2024, 13(2), 119; https://doi.org/10.3390/cells13020119 - 9 Jan 2024
Cited by 1 | Viewed by 1530
Abstract
Overcoming senescence with tissue engineering has a promising impact on multiple diseases. Here, we provide an overview of recent studies in which cellular senescence was inhibited through the up/downregulation of specific lncRNAs. This approach prevented senescence in the bones, joints, nervous system, heart, [...] Read more.
Overcoming senescence with tissue engineering has a promising impact on multiple diseases. Here, we provide an overview of recent studies in which cellular senescence was inhibited through the up/downregulation of specific lncRNAs. This approach prevented senescence in the bones, joints, nervous system, heart, and blood vessels, with a potential impact on regeneration and the prevention of osteoarthritis and osteoporosis, as well as neurodegenerative and cardiovascular diseases. Senescence of the skin and liver could also be prevented through the regulation of cellular levels of specific lncRNAs, resulting in the rejuvenation of cells from these organs and their potential protection from disease. From these exciting achievements, which support tissue regeneration and are not restricted to stem cells, we propose lncRNA regulation through RNA or gene therapies as a prospective preventive and therapeutic approach against aging and multiple aging-related diseases. Full article
(This article belongs to the Special Issue LncRNAs: Biofunctions, Cellular Targets, and Applications)
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