New Insights into Channelopathies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 28 February 2025 | Viewed by 81
Special Issue Editors
Interests: bone; cell cycle; akt; Ca2+-activated K+(BK) channel; calcium ions; cell volume; trp channels; KATP and Kir channels
Special Issues, Collections and Topics in MDPI journals
Interests: channelopathies of gastrointestinal apparatus; pathophysiology of the gastrointestinal apparatus
Special Issue Information
Dear Colleagues,
Several gastrointestinal (GI) tract abnormalities, including visceral hypersensitivity, motility, and intestinal permeability alterations, have been implicated in functional GI disorders (FGIDs). Ion channels play a crucial role in all these functions. Channelopathies in gastroenterology are gaining a strong interest, and the evidence of co-relationships is increasing. For instance, mutations in the ABCC7/CFTR gene have been described as a cause of constipation and diarrhea, whereas mutations of the SCN5A gene are instead associated with irritable bowel syndrome. Furthermore, mutations of the TRPV1 and TRPA genes manifest hypersensitivity and visceral pain in sensory nerves. Recently, mice and humans affected by Cantu syndrome, which is associated with mutations of the KCNJ8 and ABCC9 genes encoding for the Kir6.1 and SUR2 subunits, showed severe dysfunction of contractility throughout the intestine. The discovery of a correlation between channelopathies and FIGDs opens new avenues for discovering new direct drug targets for specific channelopathies, holding significant implications for diagnosing and treating functional GI diseases.
Prof. Dr. Domenico Tricarico
Dr. Fatima Maqoud
Guest Editors
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Keywords
- gastrointestinal (GI) tract abnormalities
- channelopathies
- hormones
- drugs of the gastrointestinal tract
- second messenger and signaling modulation
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