Bone Mechanotransduction, Bone Metabolism and the Functional Crosstalk between Bone with Other Organs, Tissues and Systems

Dear Colleagues,

Bone is a dynamic, adaptive, and self-healing system that plays numerous critical physiological functions in the vertebrates, including locomotion, supporting the body, protecting organs, hematopoietic function, storing minerals, and endocrine function. Moreover, bone is a finely mechanosensitive organ and constantly adapts its shape and internal structure to mechanical loads. Bone homeostasis is orchestrated by several main types of bone cells, including mesenchymal stem cells (MSCs), osteoblast, osteoclast, and osteocyte. The osteoblast is responsible for bone formation, it is initiated from MSC and terminally differentiated into an osteocyte. The osteoclast is responsible for bone resorption. Bone homeostasis is maintained by the balance of bone formation and bone resorption. Disruption of this balance leads to bone diseases, such as osteoporosis and osteopetrosis. Increasing evidence has uncovered the involvement of bone cells in bone mechanotransduction, bone metabolism and the functional crosstalk between bone with other organs and tissues, the underlying molecular and cellular mechanisms, and their relationship with bone disease development and progression. This Special Issue offers an open access forum that aims to bring together a collection of original research and review articles addressing the expanding field of bone mechanotransduction, bone metabolism and the functional crosstalk between bone with other organs and tissues, the underlying molecular and cellular mechanisms of these processes, and their involvement during bone disease (e.g., osteoporosis, osteoarthritis).  Suggested potential topics cover, but are not limited to: The activities (proliferation, differentiation, apoptosis, cell senescence) of bone cells (osteoblast, osteoclast, MSCs, osteocyte) in bone mechanotransduction and bone metabolism, and the underlying mechanism; the functional crosstalk between bone with other organs, tissues and systems such as immune system, musculoskeletal system, reproductive system; and novel methods adopted for studying mechanotransduction of bone cells or bone disease research.

Dr. Zhihao Chen
Dr. Yan Zhang
Guest Editors
Ying Huai
Guest Editor Assistant

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• bone mechanotransduction
• bone metabolism
• bone remodeling
• osteoporosis
• cell senescence
• microgravity
• osteoimmunology
• musculoskeletal system
• reproductive system