Oral Cancer: Cellular and Molecular Mechanisms of Bone Invasion

Dear Colleagues,

Oral squamous cell carcinoma (OSCC) is the most prevalent of all head and neck tumors, a heterogeneous group of neoplasms that are among the most common cancers worldwide. In advanced stages, OSCC invades the adjacent jawbone, requiring resection and extensive plastic reconstruction as part of the therapeutic approach. Both tumor progression and surgical procedures may be associated with a significant loss of function of the stomatognathic system and may limit patients' health-related quality of life. To date, little is known about bone invasion in OSCC and there is an urgent need for a better understanding of the cellular and molecular mechanisms underlying these processes. This Special Issue invites scientists and clinicians to share their recent discoveries and provide insights/updates focusing on aspects of the described mechanisms of OSCC bone invasion. These include the identification and validation of targets, biomarkers of disease or response to treatment, and the contribution of exosomes, stem cells, and immune cells and other tumor stromal cells to cancer progression and therapy resistance.

We welcome your contributions.

Dr. Phillipp Brockmeyer
Dr. Boris Schminke
Prof. Dr. Francina Lozada Nur
Guest Editors

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