Cardiac Fibroblasts and Cardiac Remodeling
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 1743
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cardiac fibrosis is defined as an aberrant excess accumulation of extracellular matrix (ECM), especially collagen, which results in the adverse remodeling of the heart. If remained untreated, this adverse cardiac remodeling will lead to organ dysfunction and ultimately organ failure, or, in this case, heart failure, which is one of the leading causes of death around the world. Whilst cardiac fibroblast is responsible for maintaining the overall structure and function of the heart, factors such as inflammation and tissue injury can trigger changes in cardiac fibroblast phenotype and function. This change not only includes the excess production of extracellular matrix (such as collagen, alpha smooth muscle actin, and laminin), but also the release of cytokines and chemokines, creating a profibrotic and proinflammatory environment, hence driving the adverse remodeling of the heart.
This Special Issue of Cells aims to provide reviews and original research articles on the intricate role of cardiac fibroblasts, especially in cardiac remodeling. Articles on genetic and cellular functions, including both biochemical and mechanical aspects of cardiac fibroblasts, are highly welcome.
Dr. Alexander Widiapradja
Guest Editor
Manuscript Submission Information
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Keywords
- fibroblasts
- remodeling
- fibrosis
- ECM
- cardiac fibrosis
- cardiac remodeling
