Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1109
Special Issue Editors
Interests: kynurenine pathway metabolism; cognition; neurodegenerative disorders; schizophrenia
Interests: psychiatric and neurodegenerative disorders; cognition; kynurenine pathway; neurodevelopment; cannabinoids
Interests: kynurenines and bioenergetic; tryptophan catabolism modulation; psychiatric diseases; cognition; neurodegeneration; aging
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Special Issue Information
Dear Colleagues,
Kynurenic acid (KYNA), an endogenous neuromodulatory molecule derived from tryptophan catabolism, is increasingly understood to play major roles in CNS functions. KYNA can act on multiple biological targets, such as NMDA, α7nACh, GPR35 and aryl hydrocarbon receptors. In addition, recent novel findings suggest that KYNA could also modulate brain function by exerting antioxidant properties, interacting with the cannabinoid system and modulating gut microbiota. This has advanced our knowledge on the implications of KYNA in CNS functions, either under physiological or pathological conditions. Nevertheless, much remains to be explored regarding the role of KYNA during the normal aging process.
This Special Issue of Cells, ‘Kynurenic Acid: Unveiling Its Impact on the Brain's Neurotransmission and Neurological Disorders’, aims to collate recent preclinical and clinical studies on the relevance of KYNA in CNS, with special emphasis on the consequences of alterations in KYNA levels on neurotransmission and the importance of maintaining its physiological levels in neurological pathologies. This could shed light on the possible role of KYNA as a pathological biomarker and/or a therapeutic target for neurological disorder treatment/prevention. We invite you to submit either original research articles or reviews to this Special Issue.
Dr. Korrapati V. Sathyasaikumar
Dr. Sarah Beggiato
Dr. Verónica Pérez de la Cruz
Guest Editors
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Keywords
- kynurenic acid
- cognition
- aging
- neuromodulation
- neurodegeneration
- neurodevelopment
- neuroinflammation
- tryptophan catabolism
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