Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 2437
Special Issue Editor
Interests: pathomechanisms of renal injury; renal structural and functional
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Prolonged diabetes can lead to chronic complications and end-stage organ damage, affecting almost all the systems of the body, including the heart, eyes, kidneys, brain, blood vessels, digestive system, skin, sexual organs, teeth, gums, feet and nerves. The damage can involve both large (macrovascular) and small (microvascular) blood vessels, leading to fatal conditions such as heart attack, stroke, kidney failure, ocular disorders and neuronal damage. The severity and duration of diabetes play a major role in determining the extent of organ involvement and subsequent damage. Altered glucose homeostasis can lead to cellular stress and mitochondrial dysfunction, contributing to the evolvement of nephropathy, cardiomyopathy, neuropathy and retinopathy.
Therapeutic opportunities for diabetes encompass a wide range of approaches, including medications, stem cell therapy and targeting cellular events. Medications such as incretin mimetics, amylin analogs and GIP analogs have shown potential benefits for controlling diabetes. Additionally, recent developments in stem cell therapy offer a promising approach to addressing the disease and its complications. Targeting cellular events, such as senescent cells and the senescence-associated secretory phenotype (SASP), represents significant opportunities for delaying the progression of type 2 diabetes and its complications. Furthermore, pancreatic β-cell endoplasmic reticulum stress has been identified as a promising therapeutic approach for addressing dysregulated insulin hypersecretion in diabetes mellitus. These diverse therapeutic opportunities provide hope for the more effective and targeted management and treatment of diabetes and its associated complications. Despite progress in understanding the etiology of diabetic injuries, there are knowledge gaps on subcellular mechanisms and effective therapeutic strategies in diabetes-induced organ damage.
This Special Issue welcomes the submission of clinical and basic science research manuscripts related to a wide range of diabetic injuries and newer treatment approaches, emphasizing the cellular mechanisms underlying diabetes-induced organ damage, therapeutic opportunities for diabetes-induced organ damage and ways in which insulin resistance contributes to diabetes-induced organ damage.
The submission may encompass original manuscripts (unpublished research works) and updated reviews (of the existing literature). The aim is to provide a broad and holistic updated knowledge of structural and functional organ impairment mechanisms during the progression of diabetes.
Preliminary studies including the effects of the ongoing pandemic or repeated vaccination on diabetes are also welcome.
Prof. Dr. Mohammed S. Razzaque
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes mellitus
- vascular lesions
- nephropathy
- cardiomyopathy
- neuropathy
- retinopathy
- therapeutic opportunities
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
