Molecular Mechanisms Underlying Inflammatory Pain
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 April 2026 | Viewed by 49
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammatory pain remains a major clinical challenge, diminishing quality of life for millions of individuals and imposing a heavy burden on healthcare systems worldwide. Despite its prevalence, effective and safe treatments have long been elusive, highlighting the urgent need for deeper mechanistic insight.
Recent advances in single-cell omics, viral-mediated gene editing, and human-derived cell models are shedding new light on how immune mediators, ion channels, and intracellular signaling pathways contribute to nociceptor sensitization and chronic pain states. These discoveries are beginning to translate into transformative therapies. The recent FDA approval of suzetrigine, a selective peripheral NaV1.8 channel blocker and the first non-opioid analgesic approved in decades, highlights how molecular insights can directly inform the development of safer and more effective treatments.
This Special Issue will bring together cutting-edge research and reviews on the molecular and cellular mechanisms underlying inflammatory pain. We particularly welcome contributions addressing neuroimmune interactions, ion channel regulation, intracellular signaling and translational strategies aimed at advancing diagnosis, prevention, and therapy.
Dr. Luke A. Pattison
Guest Editor
Manuscript Submission Information
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Keywords
- molecular mechanisms
- inflammatory pain
- nociception
- neuronal sensitization
- neuroimmune interactions
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