Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.9
5.1
Journals
Cells
Special Issues
Innate-Acquired Linkage in Immunotherapy—Series II
share announcement

Innate-Acquired Linkage in Immunotherapy—Series II

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (10 January 2024) | Viewed by 2417

Special Issue Editor

Prof. Dr. Tsukasa Seya

E-Mail Website
Guest Editor
Nebuta Research Institute for Health Sciences, Aomori University, Kobata 2-3-1, Aomori 030-0943, Japan
Interests: dendritic cells; toll-like receptor; cool adjuvant (immune-enhancer without inflammation)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

A variety of immune cells join the maintenance of homeostasis against environmental emergencies and occurrences. The immune system is categorized into innate and acquired systems, and vertebrates, including humans, possess a network constituting innate–acquired linkage. T lymphocyte proliferation and activation is rooted in dendritic cell/macrophage signal in the context of innate pattern sensing. Antigen-presenting dendritic cells consist of unique subsets and enhance T cell proliferation and antibody production by B cells. Pattern-sensing renders inflammatory profiles multifarious in a cell-type-specific manner, in some cases reaching prolonged inflammation, resulting in chronic diseases. Thus, the regulation of an excess inflammatory response is indispensable for a healthy life. Many cell types have their own unique innate/acquired response depending on environmental factors. However, the mechanisms whereby the immune system produces homeostasis in disease states remain largely to be elucidated. Immune enhancers called adjuvants, blockades of checkpoint inhibitors, dying cells, and damage-associated molecular patterns (DAMP) all accelerate the inflammatory status in their environmental context. The purpose of this new edition of the Special Issue on ‘Innate–Acquired Linkage in Immunotherapy—Series II’ is to develop a better understanding of immune regulation in inflammation-related diseases. 

Prof. Dr. Tsukasa Seya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dendritic cells
  • Toll-like receptor
  • checkpoint inhibitor
  • innate lymphocyte
  • microenvironment
  • dying cell alarm
  • inflammation

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Review

14 pages, 703 KiB  
Review
Two Modes of Th1 Polarization Induced by Dendritic-Cell-Priming Adjuvant in Vaccination
by Tsukasa Seya, Masashi Shingai, Tomomi Kawakita and Misako Matsumoto
Cells 2023, 12(11), 1504; https://doi.org/10.3390/cells12111504 - 29 May 2023
Cited by 3 | Viewed by 2084
Abstract
Viral infections are usually accompanied by systemic cytokinemia. Vaccines need not necessarily mimic infection by inducing cytokinemia, but must induce antiviral-acquired immunity. Virus-derived nucleic acids are potential immune-enhancers and particularly good candidates as adjuvants in vaccines in mouse models. The most important nucleic-acid-sensing [...] Read more.
Viral infections are usually accompanied by systemic cytokinemia. Vaccines need not necessarily mimic infection by inducing cytokinemia, but must induce antiviral-acquired immunity. Virus-derived nucleic acids are potential immune-enhancers and particularly good candidates as adjuvants in vaccines in mouse models. The most important nucleic-acid-sensing process involves the dendritic cell (DC) Toll-like receptor (TLR), which participates in the pattern recognition of foreign DNA/RNA structures. Human CD141+ DCs preferentially express TLR3 in endosomes and recognize double-stranded RNA. Antigen cross-presentation occurs preferentially in this subset of DCs (cDCs) via the TLR3–TICAM-1–IRF3 axis. Another subset, plasmacytoid DCs (pDCs), specifically expresses TLR7/9 in endosomes. They then recruit the MyD88 adaptor, and potently induce type I interferon (IFN-I) and proinflammatory cytokines to eliminate the virus. Notably, this inflammation leads to the secondary activation of antigen-presenting cDCs. Hence, the activation of cDCs via nucleic acids involves two modes: (i) with bystander effect of inflammation and (ii) without inflammation. In either case, the acquired immune response finally occurs with Th1 polarity. The level of inflammation and adverse events depend on the TLR repertoire and the mode of response to their agonists in the relevant DC subsets, and could be predicted by assessing the levels of cytokines/chemokines and T cell proliferation in vaccinated subjects. The main differences in the mode of vaccine sought in infectious diseases and cancer are defined by whether it is prophylactic or therapeutic, whether it can deliver sufficient antigens to cDCs, and how it behaves in the microenvironment of the lesion. Adjuvant can be selected on a case-to-case basis. Full article
(This article belongs to the Special Issue Innate-Acquired Linkage in Immunotherapy—Series II)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop