Defining the Role That Cellular Membranes Play during Virus Replication
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 207
Special Issue Editor
Interests: RNA viruses; virus particle assembly; host-cell factors; lipid-raft microdomains
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Viruses are obligate intracellular parasites, and in this context, the efficient replication and transmission of the virus depends on an intimate interaction between the virus and the living host cell. Although the nature of this interaction is largely dependent on the coding capacity of the genome of the specific virus in question, all known viruses require essential host cell factors for efficient virus replication. The identification of functional interactions between the viruses and specific host cell factors is a complex and difficult task. However, the application of post-genomic enabling technologies has facilitated the unraveling of this complexity, thus enabling a better understanding of how viruses interact with their respective host. Host cell lipid membranes can directly contribute to the structural integrity of mature virus particles, and many of the essential host cell factors that have been identified are also associated with cellular membranes at different locations within the host cell. As a consequence, these cellular membranes and their associated host cell factors play pivotal roles during the different phases of the virus replication cycle. In this Special Issue, a series of articles that examine the complex role that cellular membranes and their associated cell factors play during virus replication will be presented.
Dr. Richard Sugrue
Guest Editor
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Keywords
- lipid rafts microdomains
- cell membrane
- virus–host interactions
- membrane proteins
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