Molecular Mechanism of Alzheimer's Disease: Focus on Degeneration and Proliferation in Vascular Smooth Muscle Cells
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: closed (15 June 2021) | Viewed by 7781
Special Issue Editor
Special Issue Information
Dear Colleagues,
Dysfunction of vascular smooth muscle cells (VSMCs) leads to the development of several predominant cardiovascular diseases, small vessel diseases that lead to vascular dementia. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) represents the most common form of inherited stroke and vascular dementia, and a very large number of individuals worldwide suffer from the disease. We have set up studies to investigate VSMC degeneration, which is involved in many vascular-related disorders. Moreover, we have had the ambition to investigate several biological issues related to CADASIL pathogenesis that also provides the opportunity for studying VSMC proliferation and ECs involved in vascular disorders. We have demonstrated a new possible treatment candidate of tumor growth factor beta not only for CADASIL but also in vascular-related diseases. We have also investigated the possible cause of accumulation/aggregation of NOTCH3 in CADASIL and shown an accumulation of autophagosomes in CADASIL. Further, we have studied whether brain glucose metabolism is disrupted in VSMCs in CADASIL. Our studies can open up a new area of potential therapeutic targets in CADASIL. The possibility of discovering new treatment targets in cellular pathways where pathology predates much of the VSMCs degeneration observed in CADASIL brings new hope in the field where many current clinical treatments have failed.
This Special Issue aims to summarize the current knowledge on degeneration and proliferation in vascular smooth muscle cells.
Dr. Homira Behbahani
Guest Editor
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Keywords
- dysfunction of vascular smooth muscle cells (VSMCs)
- Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
- vascular dementia
- degeneration
- proliferation
- vascular smooth muscle cells
