How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 74
Special Issue Editors
Interests: cancer immunology; macrophages; myeloid-derived suppressor cells; γδ T cells; flow cytometry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The immune system is capable of reacting with malignant cells. However, this response is typically unsuccessful in advanced cancer. Cancer cells have developed complex mechanisms to prevent the immune system from detecting and eliminating them. Tumour antigen expression changes, increases in immune checkpoint receptor levels, metabolic networks, hypoxia, and the production of immunosuppressive factors are some of the mechanisms involved. In addition, the various triggered pathways can reprogram immune cells towards a regulatory phenotype or drive them into anergy. Therefore, to design new and more efficient anticancer treatments, it is necessary to understand the factors of the tumour microenvironment (TME) that affect the efficacy of immunotherapy. Oncological research requires a thorough understanding of the crosstalk between the tumour and the immune system.
This Special Issue is designed to encourage the exchange of findings in immuno-oncology related to cancer immune evasion, immunosuppression, and the microenvironment. Papers dealing with strategies for optimising cancer immunotherapy are especially welcome. Innovative original papers and reviews are within the scope of this Special Issue.
Prof. Dr. Agnieszka Bojarska-Junak
Prof. Dr. Michal Zarobkiewicz
Guest Editors
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Keywords
- immunosurveillance
- immune evasion in cancer
- tumour microenvironment
- immune suppression
- immunotherapy
- immune checkpoints
- cancer immunity
- drug intervention
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