Intrinsically Disordered Proteins in Host Function and Subversion by Pathogens
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 13463
Special Issue Editors
Interests: antiviral immunity; infection; nucleocytoplasmic transport; immune evasion host-pathogen interactions
Special Issues, Collections and Topics in MDPI journals
2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia
Interests: regulation of nucleocytoplasmic transport; viral infection; stress biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Many proteins critical to cell function as well as pathogenic conditions are intrinsically disordered proteins (IDPs) or contain intrinsically disordered regions (IDRs). These IDP/IDRs lack persistent structure in solution, and their inherent plasticity enables them to bind to multiple partners. This is integral to host processes such as transport into and out of the nucleus, which in turn is central to cell signalling in innate immune responses. The ability to bind to multiple partners is also key to the strategies pathogens use to circumvent the innate immune response. Clearly, delineating the relationship between IDP/IDR structure and function is central to understanding the host–pathogen interface.
This relationship is complicated, however, by the fact that inherent lack of structure hampers high-resolution structure determination. Innovative approaches are required to give insight into the molecular detail and dynamics of IDPs/IDRs, how this impacts host cell function and how it is exploited by pathogens.
This Special Issue will focus on the basic biology of host- and pathogen-derived IDRs and IDPs, as well as their contribution to innate immunity and infection.
Dr. Natalie Borg
Prof. David A. Jans
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Intrinsically disordered protein
- Unstructured proteinsare