Key Cells in the Pathogenesis, Diagnosis and Treatment of Allergies

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 791

Special Issue Editor


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Guest Editor
Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, A-1090 Vienna, Austria
Interests: allergy; allergen; vaccines; immunology; antibodies; virus infections

Special Issue Information

Dear Colleagues,

Immunoglobulin E (IgE)-associated allergies are important immunologically mediated hypersensitivity diseases. Currently, more than 30% of the world’s population experiences allergies, including a broad spectrum of symptoms in different organs. Various cells belonging to the adaptive and innate immune cells orchestrate allergic inflammation and contribute to the pathogenesis of allergies. In addition to the measurement of allergen-specific IgE antibodies, there are several cell-based diagnostic tests for allergies. Furthermore, a variety of therapeutic strategies are currently being developed that target cells involved in allergic inflammation. Which therapeutic strategy will be the most effective and economical for the treatment and prevention of allergies in the future is an open question. This Special Issue is dedicated the role of immune cells in the pathogenesis, diagnosis, treatment and prevention of allergies. 

Prof. Dr. Rudolf Valenta
Guest Editor

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Keywords

  • allergy
  • immunoglobulin E
  • allergen
  • immune cell
  • diagnosis
  • pathogenesis
  • therapy
  • prevention

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Published Papers (1 paper)

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Research

14 pages, 1222 KiB  
Article
Eosinophil–Basophil/Lymphocyte (EB/LR) and Eosinophil–Basophil–Platelet/Lymphocyte (EBP/LR) Ratios Could Serve as Useful Additional Markers for Assessing the Severity of Wasp Allergic Reactions
by Weronika Urbańska, Łukasz Szymański, Aneta Lewicka, Martyna Ciepielak, Karolina Kostrzeńska-Sęk, Andrzej Chciałowski and Sławomir Lewicki
Cells 2024, 13(21), 1786; https://doi.org/10.3390/cells13211786 - 28 Oct 2024
Viewed by 608
Abstract
Wasp venom allergy can trigger severe allergic reactions, and predicting these acute responses remains challenging. This study evaluates the utility of immune system indexes, particularly the eosinophil–basophil/lymphocyte (EB/LR) and eosinophil–basophil–platelet/lymphocyte (EBP/LR) ratios, in assessing the severity of allergic reactions in patients with wasp [...] Read more.
Wasp venom allergy can trigger severe allergic reactions, and predicting these acute responses remains challenging. This study evaluates the utility of immune system indexes, particularly the eosinophil–basophil/lymphocyte (EB/LR) and eosinophil–basophil–platelet/lymphocyte (EBP/LR) ratios, in assessing the severity of allergic reactions in patients with wasp venom allergy. A total of 61 patients with confirmed wasp venom allergy were categorized according to the Mueller scale, which classifies the severity of allergic reactions. Blood samples were analyzed for total and specific IgE levels alongside a range of hematological and biochemical parameters. This study found significant differences in the EB/LR and EBP/LR indexes between patients with mild (Mueller I–II) and severe (Mueller III–IV) allergic reactions, with higher values indicating more severe responses. However, no significant differences were observed in other immune indexes, such as the platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and systemic inflammatory response index, as well as in additional blood parameters. These findings suggest that the EB/LR and EBP/LR ratios may serve as useful markers for predicting the severity of allergic reactions in patients with wasp venom allergy. This is the first study to establish such a link, although further research with larger cohorts is necessary to confirm these results and their potential application in clinical settings. Full article
(This article belongs to the Special Issue Key Cells in the Pathogenesis, Diagnosis and Treatment of Allergies)
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