Role of Cell Organelles in Normal Aging, Senescence, and Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Aging".
Deadline for manuscript submissions: 15 March 2025 | Viewed by 220
Special Issue Editors
Interests: cancer stem cells; cancer metabolism; tumour recurrence and metastasis; drug resistance; clinical trials
Special Issues, Collections and Topics in MDPI journals
2. Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA
3. Department of Radiology, Georgetown University Medical Center, Washington, DC 20057, USA
Interests: cancer biology; drug resistance; GI cancers; imaging sciences; magnetic resonance imaging (MRI); neurologic; brain; CNS cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organismal and cellular aging is a chronological process that may be the result of accumulated damage, including REDOX-related modifications of DNA, RNA and lipids, as well as protein aggregation, resulting in cellular dysfunction. However, the root cause of aging remains a debated topic and is an area of great interest to the research community. The number of aging-associated diseases is high, and these include cancer, diabetes and heart disease, as well as dementia and other neuro-degenerative disorders.
One of the hallmarks of aging is the appearance of senescent cells. These cells undergo cell cycle arrest mostly due to the up-regulation of cyclin-dependent kinase inhibitors (p16, p19-ARF and p21-WAF), and increase their biosynthetic production of inflammatory mediators that are part of the SASP (senescence-associated secretory phenotype), such as IL-1-beta, IL-6, and IL-8, etc.
Senescent cells also show characteristic morphological and functional organellar changes in their nuclei, mitochondria, lysosomes and endocytic capacity.
This Special Issue will explore the fundamental role of cell organelles in senescence, the aging process and senescence escape in cancer cells. Comprehensive reviews and original articles are both welcome. There will also be a focus on the mitochondrial–lysosomal axis of aging.
Dr. Michael Lisanti
Dr. Christopher Albanese
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- aging
- accumulated damage
- ROS-induced damage
- protein aggregation
- senescence
- cancer
- senescence escape
- cell organelles
- mitochondria
- lysosomes
- SASP
- inflammation
- IL1-beta/IL-6/IL-8
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
