RNA Interference (RNAi): Mechanisms and Applications
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 433
Special Issue Editor
Interests: cancer biology and cancer therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
RNA interference (RNAi) is a conserved gene-regulation mechanism in all eukaryotic cells, where micro-RNA (miRNA), small interfering RNA (siRNA), and small hairpin RNA (shRNA) interact with mRNAs in a sequence-specific way and lead to the cleavage or translational blockage of the gene. Since its discovery in 1996, it has been widely used as a powerful tool for gene function studies in biology laboratories worldwide. In addition, because the blockage is sequential-specific and at the transcriptional level, RNAi-mediated gene silencing (RNAi therapy) is believed to hold great promise for effectively treating many diseases. For example, RNAi has been proven to be effective in gene therapy for viral infections, genetic disorders, and cancers.
Thanks to recent advances in drug delivery systems, especially advanced nanotechnology, siRNA delivery has seen great progress and exciting new results, bringing RNAi therapy much closer to clinical application. So far, several RNAi products have been successful on the market. In addition to RNAi therapy, another area attracting attention is the relationship between the RNAi pathway and host immune system; that is, RNAi not only involves innate immunity but also adaptive immunity. A better understanding of this relationship and combination of gene silencing with induced immunity will lead to more effective and safer therapies for cancer or other diseases.
Dr. Wenyi Gu
Guest Editor
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Keywords
- RNA interference
- gene therapy
- gene silencing
- miRNA /therapy
- drug/siRNA delivery
- RNAi and immunity
- miRNA and immunity
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