Natural Killer Cells in Cancer Immunotherapy: Molecular Mechanisms, Diagnostic and Therapeutic Opportunities
Special Issue Editor
Interests: innate immunity; NK cells; cytokines; immunomodulation; oncology; hematology; biochemistry; tumor markers; molecular markers; polymorphisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Since the discovery and first description of natural killer (NK) cells, a special population of peripheral blood lymphocytes, these cells have received great scientific interest. NK cells were first described as large granular lymphocytes with a specific morphology and role in oncology. Today, with the help of new technologies of molecular medicine and multicolor flow cytometry, the focus of global research is the examination of markers responsible for the activation and inhibition of NK cells, as well as gene regulation, in light of understanding tumor suppression in oncology patients. NK cell function is also based on a specifically adjusted balance between signals arising from inhibitory and activating receptors in contrast to T cytotoxic lymphocytes.
Based on the latest knowledge and information about NK cells, this Special Issue aims to further discuss and analyze the new molecular mechanisms involved in the regulation of NK cells and their importance in disease diagnosis and during progression, with special reference to the balance between the immune system and cancer. At the same time, via the development of new technologies for the separation and purification of the NK cell population, ex vivo manipulation has enabled the use of NK cells in immunotherapy and transplantation. We hope that such research and original results will provide new and realistic knowledge about the possibilities of treating malignant diseases, as well as an understanding of all the complex processes and principles of immunology. Together, this can be of great importance in clinical practice. That is why we invite authors from this field to contribute new knowledge about NK cells.
Prof. Dr. Vladimir Jurisic
Guest Editor
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Keywords
- natural killer cells
- immunotherapy
- solid tumors
- tumor suppression
- immunomodulation
- clinical practice
