Tumor Stroma Interaction
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 20 November 2025 | Viewed by 676
Special Issue Editor
Interests: innate immunity; NK cells; cytokines; immunomodulation; oncology; hematology; biochemistry; tumor markers; molecular markers; polymorphisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The relationship between cancer cells and the immune system represents a very complex interaction that is not fully understood. It is known that the cells in the tumor environment are suppressed so that they cannot perform an adequate induction of tumor cell apoptosis and so that the immune response is avoided by the tumor. For many years, the research focus was on general immunotherapy and immunostimulation. However, today we are working toward a better understanding of the phenomenon of immunosuppression of the immune system. Drugs that block the key points of immunosuppression do exist; however, despite research into the role of individual molecules and the creation of new drugs that block certain key molecules, as are in use today, resistance and insufficient tumor elimination remain. That is why research is necessary, and we require a better and more comprehensive understanding of these complex interactions in order to apply a new possibility of immune modulation based on new potential molecules. The aim of this Special Issue is to focus on better explaning mediators, cellular signals, individual cell subsets, and their surface markers, which participate in the complex interaction of a tumor and the immune system. At the same time, there is a need for a better understanding of immunomodulation and, finally, for an examination of the possibility of applying new and obtained findings in clinical work. Based on newly obtained research data, there remains hope that tumor treatment will be improved in the near future, based on individual therapy created for each individual and based on individual changes in each individual subject.
Prof. Dr. Vladimir Jurisic
Guest Editor
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Keywords
- cells
- cancer
- inflammation
- exocytosis
- immune system
- tumor stroma
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