Programming and Reprogramming the Tumor Microenvironment
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".
Deadline for manuscript submissions: closed (25 August 2023) | Viewed by 1626
Special Issue Editor
Special Issue Information
Dear Colleagues,
One of the key hallmarks of cancer is the functional reprogramming of healthy tissue to support tumor growth. The tumor cells and the surrounding tumor-associated tissue form a complex functional unit called the tumor microenvironment (TME). Major cells targeted for TME programming include macrophages (TAM), myeloid-derived suppressor cells (MDSC), somatic stem cells, fibroblasts (CAF), endothelial cells (EC), adipocytes (AC), and others. Tumor-driven programming of the TME is a significant barrier to conventional, state-of-the-art chemotherapies and cell- and antibody-based (checkpoint) therapies. Understanding the changes in cellular function and communication within the TME can provide new tools to overcome therapy resistance.
This Special Issue will examine tumor-mediated programming of the above-mentioned cell types at the cellular and molecular levels, address cell-to-cell communication among tumor cells and cells of the tumor-associated stroma (TAS). Papers that describe models or approaches to reprogram TME (TAM, MDSC, EC and CAF) to reverse the tumor-promoting physiological state and overcome therapy resistance are also invited for submission.
Dr. Árpád Lanyi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- myeloid-derived suppressor cells
- tumor-associated macrophages
- cancer-associated fibroblast
- metabolic reprogramming
- immune metabolism
- combination therapies
- TME reprogramming
- checkpoint therapy
- therapy resistance
