Complex Role of Cilium-Generated Signaling
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 July 2023) | Viewed by 4327
Special Issue Editors
Interests: primary cilia structure and function; cell and tissue biomechanics and mechanobiology; organ-on-a-chip in vitro models
Special Issue Information
Dear Colleagues,
In the last thirty years, primary cilia have gone from organelles that few believed existed, let alone had any function, to ones that are now known to be involved in an expanding array of cell signalling pathways important for human development, health, and disease.
When Satir, Pedersen, and Christensen published their seminar review of primary cilia in 2010 (J Cell Sci), they described key cilia signalling pathways, including hedgehog signalling, growth factor signalling, mechanosignalling, and planar cell polarity. Since then, our mechanistic understanding of the role of primary cilia and associated proteins in these signalling pathways has hugely expanded. These pathways are coordinated on or by the cilium and associated structures and are canonically dependent on the process of intraflagellar transport (IFT) to shuttle signalling proteins on and off the axoneme.
Studies are now identifying new cilia signalling pathways and the role of specific cilia-associated proteins. Other studies are beginning to unravel the fundamental structure–function relationships that govern cilia signalling behaviour, as well as the involvement of defined regions of the cilia complex, including the basal body and ciliary pocket. There is an increasing understanding of how multiple different factors within the biochemical and biophysical cellular environment can modulate cilia structure and function. This research is supported by whole-genome sequencing and the omic revolution, which reveal new information linking cilia and associated signalling with disease. This leads to exciting studies exploring the therapeutic potential of ciliatherapy, involving cilia modulation through either pharmaceutical or genetic intervention, to control cilia signalling.
This Special Edition on cilia signalling welcomes articles covering all aspects of cilia signalling, from individual molecule to whole system and organism biology.
Prof. Dr. Martin Knight
Dr. Angus Wann
Guest Editors
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Keywords
- primary cilia
- signalling
- structure
- ciliopathy
- ciliatherapy
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