Effective Embryo Maternal Interaction Support Favorable Pregnancy Outcome
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 March 2025 | Viewed by 32
Special Issue Editors
2. Gynecology & Reproductive Sciences, School of Medicine, University of Miami Miller, Miami, FL, USA
Interests: conception; implantation; early pregnancy; signaling; embryo–maternal interaction; diagnosis; prevention and therapy
2. IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy
Interests: high risk pregnancy; recurrent miscarriage; preterm delivery; autoimmune diseases; diabetes and pregnancy; preeclampsia; cardiovascular diseases and pregnancy; microbiota; infertility; menopause; fertility
Special Issues, Collections and Topics in MDPI journals
Interests: infant
Special Issue Information
Dear Colleagues,
Early pregnancy development evolving from structure to function is essential for favourable pregnancy outcomes. It covers several intercalating obligatory steps where each can be a binary outcome leading to progress vs. failure. Events from pre-conception, fertilization, tubal transport and implantation until embryogenesis remain largely clinically silent, limiting diagnostic and therapeutic interventions. Fertilization requires appropriate timing, since ovulation occurs only monthly while sperm presence is continuous. The ovulation quality is essential, minimizing premature or post mature egg fertilization, where the failure rate is ~50%. Only viable embryos initiate maternal communication via specific signalling, enabling the decidual recognition of pregnancy. Effective priming during the narrow implantation window is required for blastocyst implantation. Ensuing endometrial receptivity, combined with systemic maternal tolerance without immune suppression, permits embryogenesis to start. These are highly ordered obligatory events where deviations exert a significant negative impact, with ~20% loss rate or even more. Successfully completed embryogenesis reflects integrated functionality where the progress of foetal development is established. This is coupled with trophoblast vascularization, providing nutrients and oxygen through the placenta. Subsequently, the further loss rate is minimal due to the prior-established rigorous embryo-self and maternal quality control measures. An improved insight into the complexity of early pregnancy events will have a major positive impact in improving pregnancy outcomes.
Dr. Eytan R. Barnea
Prof. Dr. Nicoletta Di Simone
Dr. Guarano Alice
Guest Editors
Manuscript Submission Information
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Keywords
- pregnancy
- fertilization
- tubal transport
- embryogenesis
- maternal quality control
