Molecular Mechanism of Lymphoma

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".

Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 3604

Special Issue Editor


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Guest Editor
Department of Experimental, Diagnostic, and Specialty Medicine, Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy
Interests: leukemia; lymphoma; targeted therapy; molecular diagnostics; high throughput genomics; transcriptomics
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Special Issue Information

Dear Colleagues,

The recent improvements in the knowledge of the molecular pathogenesis of malignant lymphoma have offered a new rational basis for innovative approaches as far as both diagnostics and therapies are concerned. However, on the other hand, recent studies, especially those based on next-generation sequencing, also highlighted the complexity of these disorders. Like opening Pandora’s box, a tremendous amount of information was released, needing more and more investigations to fully understand the consequences of specific lesions as well as the potential interaction across affected proteins and pathways.  Furthermore, the alteration of cellular metabolism has emerged as a prominent character in lymphoma development and progression.

This Special Issue aims to provide new concepts and ideas on the pathobiology of human lymphomas in terms of pathology, genetics, cell metabolism and biomarker discovery. New experimental findings (research articles) as well as reviews (the latter requiring preliminary contact with the Editor before submission), communications, and editorials are acceptable and will be considered.

The objective is to eventually favor the translation of genomic and pre-clinical findings into concrete benefits for lymphoma patients. 

Prof. Dr. Pier Paolo Piccaluga 
Guest Editor

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Keywords

  • lymphoma
  • pathology of lymphoma
  • tumor metabolism 
  • molecular pathogenesis 
  • pathogens driven lymphoma 
  • molecular diagnosis 
  • targeted therapy

Published Papers (1 paper)

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22 pages, 2554 KiB  
Systematic Review
Meta-Analysis of MS-Based Proteomics Studies Indicates Interferon Regulatory Factor 4 and Nucleobindin1 as Potential Prognostic and Drug Resistance Biomarkers in Diffuse Large B Cell Lymphoma
by Mostafa Ejtehadifar, Sara Zahedi, Paula Gameiro, José Cabeçadas, Maria Gomes da Silva, Hans C. Beck, Ana Sofia Carvalho and Rune Matthiesen
Cells 2023, 12(1), 196; https://doi.org/10.3390/cells12010196 - 3 Jan 2023
Cited by 2 | Viewed by 3112
Abstract
The prognosis of diffuse large B cell lymphoma (DLBCL) is inaccurately predicted using clinical features and immunohistochemistry (IHC) algorithms. Nomination of a panel of molecules as the target for therapy and predicting prognosis in DLBCL is challenging because of the divergences in the [...] Read more.
The prognosis of diffuse large B cell lymphoma (DLBCL) is inaccurately predicted using clinical features and immunohistochemistry (IHC) algorithms. Nomination of a panel of molecules as the target for therapy and predicting prognosis in DLBCL is challenging because of the divergences in the results of molecular studies. Mass spectrometry (MS)-based proteomics in the clinic represents an analytical tool with the potential to improve DLBCL diagnosis and prognosis. Previous proteomics studies using MS-based proteomics identified a wide range of proteins. To achieve a consensus, we reviewed MS-based proteomics studies and extracted the most consistently significantly dysregulated proteins. These proteins were then further explored by analyzing data from other omics fields. Among all significantly regulated proteins, interferon regulatory factor 4 (IRF4) was identified as a potential target by proteomics, genomics, and IHC. Moreover, annexinA5 (ANXA5) and nucleobindin1 (NUCB1) were two of the most up-regulated proteins identified in MS studies. Functional enrichment analysis identified the light zone reactions of the germinal center (LZ-GC) together with cytoskeleton locomotion functions as enriched based on consistent, significantly dysregulated proteins. In this study, we suggest IRF4 and NUCB1 proteins as potential biomarkers that deserve further investigation in the field of DLBCL sub-classification and prognosis. Full article
(This article belongs to the Special Issue Molecular Mechanism of Lymphoma)
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