Autophagosome–Lysosome Fusion
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Autophagy".
Deadline for manuscript submissions: closed (15 September 2023) | Viewed by 4517
Special Issue Editor
Interests: lysosomal storage disorders; autophagy–lysosomal pathway; sphingolipids metabolism; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The autophagy–lysosomal pathway (ALP) is a cellular clearance pathway essential for organelle turnover, clearance of unwanted molecules and proteins, and energy homeostasis. Autophagosome–lysosome fusion is the formation of hybrid organelles when autophagosomes fuse with lysosomes to degrade components in the cytoplasm. Failure at any of these steps sets off a cascade of events that lead to tissue degeneration, genomic instability, cancer, and the inhibition of immune defense against infections. Impaired ALP is associated with a variety of diseases, including lysosomal storage disorders, neurodegenerative diseases, cancer, muscular disorders, cardio, kidney diseases, and pathogen infections.
This research topic focuses on the current understanding of molecular mechanisms of ALP and outlines autophagy-specific lysosomal research in the pathogenesis of diseases. Publications related to new biomarkers and novel therapies highlighting ALP as a therapeutic target are welcome.
We encourage authors to submit original research articles, clinical cases, and reviews that will increase our understanding of the cellular mechanisms underlying the role of lysosomes in autophagy in general and diseases. We also encourage undergraduate and graduate students and postdoctoral trainees to write reviews.
Potential topics include, but are not limited to:
- Omics approaches to study autophagy and lysosomes;
- Imaging approaches to study the dynamic of autophagy and lysosomes;
- Lysosomal enzymes;
- Chemical modulators of autophagy and lysosomes as a novel therapeutic target;
- Physiology and mechanisms of autophagosome formation;
- Autophagy and proteostasis;
- Autophagy and aging, cancer, and neurodegenerative diseases;
- Lysosomal storage diseases;
- Selective autophagy (mitophagy, endosomal microautophagy);
- Autophagy and model organisms;
- Autophagy or lysosomal biomarkers as a diagnostic tool.
Dr. Margarita Ivanova
Guest Editor
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Keywords
- autophagy
- lysosome
- cancer
- neurodegenerative diseases
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