Mitochondria, Metabolism and Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Mitochondria".
Deadline for manuscript submissions: closed (30 September 2020) | Viewed by 867
Special Issue Editor
Interests: cancer; mitochondrial metabolism; metabolic reprogramming; hybrid metabolic status; transmitochondrial cybrids and fatty acid oxidation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Though the presence of abnormal metabolic activities in cancer tissues is well-established, it remains unclear how the cellular oncogenic states lead to the unusual metabolism and how the cancer metabolism contributes to tumorigenesis. In the traditional view based on the Warburg effect, cancer cells largely depend on glycolysis to produce energy even in the presence of oxygen. However, recent developments in cancer metabolism have established that both glycolysis and oxidative phosphorylation (OXPHOS) can be active in several aggressive cancer cells. Importantly, more and more experimental evidence upholds the critical role that actively functional mitochondria play in tumorigenesis and drug resistance. It has also been proposed that the metabolic plasticity in tumor cells might play a crucial role in cancer stemness and metastasis. Cancer mitochondria can utilize different kinds of resources, such as glucose, glutamine, and fatty acids, to fuel the electron transport chain (ETC) for OXPHOS. Moreover, the involvement of mitochondria in cell death mechanisms makes them important targets for tumor therapy.
Dr. Benny Abraham Kaipparettu
Guest Editor
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Keywords
- mitochondria
- cancer metabolism
- transmitochondrial hybrids
- metabolic reprogramming
- mitochondria–nuclear crosstalk
- hybrid metabolic status
- reactive oxygen species
- glycolysis
- electron transport chain
- metabolic inhibitors
- apoptosis
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