Molecular and Epigenetic Mechanisms Regulating Neurons and Glial Cells in Health and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1911
Special Issue Editor
Interests: neurodevelopmental disorders; microglia-mediated neuroinflammation; neuropathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Modern neuroscience has revealed the increasing emphasis on neurons and glial cells as well as their crosstalk in the pathology and progression of neurodegenerative disorders. Microglia, oligodendrocytes and astrocytes perform critical roles in healthy functioning and upkeep of neurons in the brain and spinal cord. However, under pathological conditions, biomechanisms governing this cellular milieu begin to dysregulate the microenvironment in pursuit of reinstating homeostasis; this initiates molecular, and epigenetic cascades that more often than not turn detrimental to neuronal function through numerous pathways involving factors such as inflammatory cytokines, proteinopathies and impaired neuron–glia communication leading to events such as excitotoxicity. It has become imperative to approach neurological disorders that may be pathological (i.e., strokes, spinal cord injury) or physiological (i.e., Alzheimer’s dementia, age-associated cognitive deficits) from the perspective of understanding glia and their complex role in the induction and evolution of such disorders.
In this Special Issue of Cells, we look forward to publishing original research articles and reviews on the mechanisms of neurons and glial and their roles in neurological and neurodegenerative conditions. We hope that this approach shall be constructive towards realizing breakthroughs and improved therapeutic strategies for neurological conditions.
Porf. Dr. S. Thameem Dheen
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegenerative disorders
- neurons
- glial cells
- neuropathology
