Neuroregeneration in Neurodegenerative Disease

Dear Colleagues,

Neurodegeneration induced by disease and/or trauma commonly leads to drastic alterations in patients’ life, imposing severe limitations to their daily lives, as well as those of their relatives. Indeed, neurodegenerative diseases, epilepsy, neuromuscular disorders, spinal cord, and traumatic brain injuries, or stroke, just to mention a few, often pose unique challenges for treatment. The latter are mainly due to the low regenerative potential of the central nervous system. The nervous system, unlike many other tissues, has a limited capacity for self-repair. Therefore, there is a great interest in the possibility of repairing the nervous system using strategies that can replace the lost cell population or, alternatively, induce local neuronal proliferation, differentiation, and modulation of the local inflammatory environment. Routes such as stem cell transplantation and cell secretome administration have been shown to improve the conditions of several animal models of injury and disease of the CNS. On the other hand, bioengineering approaches, in which the brain–spinal cord or brain machine interface with each other, and biomaterials in the forms of hydrogels and nanoparticles, with or without combination with stem cells, have also achieved positive results. Finally, with the advent of new biomolecular tools, such as CRIPR-Cas9, other avenues have been opened for the possible regeneration/repair of the CNS. Having this in consideration, the present Special Issue aims to address the most recent developments in this field, particularly targeting those that lead to neurogeneration and with it induce functional repair.

Prof. Dr. António Salgado
Guest Editor

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Dear Colleagues,

Neurodegeneration induced by disease and/or trauma commonly leads to drastic alterations in patients’ life, imposing severe limitations to their daily lives, as well as those of their relatives. Indeed, neurodegenerative diseases, epilepsy, neuromuscular disorders, spinal cord, and traumatic brain injuries, or stroke, just to mention a few, often pose unique challenges for treatment. The latter are mainly due to the low regenerative potential of the central nervous system. The nervous system, unlike many other tissues, has a limited capacity for self-repair. Therefore, there is a great interest in the possibility of repairing the nervous system using strategies that can replace the lost cell population or, alternatively, induce local neuronal proliferation, differentiation, and modulation of the local inflammatory environment. Routes such as stem cell transplantation and cell secretome administration have been shown to improve the conditions of several animal models of injury and disease of the CNS. On the other hand, bioengineering approaches, in which the brain–spinal cord or brain machine interface with each other, and biomaterials in the forms of hydrogels and nanoparticles, with or without combination with stem cells, have also achieved positive results. Finally, with the advent of new biomolecular tools, such as CRIPR-Cas9, other avenues have been opened for the possible regeneration/repair of the CNS. Having this in consideration, the present Special Issue aims to address the most recent developments in this field, particularly targeting those that lead to neurogeneration and with it induce functional repair.