Pathogenesis of Osteosarcoma
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 10785
Special Issue Editor
Interests: osteosarcoma; preclinical models of osteosarcoma; metastasis; tumor microenvironment; tumor immunology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Osteosarcoma is the most common primary malignant tumor of bone. Recent advances in combination therapy involving surgery and chemotherapy have dramatically improved prognosis. However, patients with advanced stages do not survive over the long term, which has remained unchanged over the past 30 years. To develop promising therapeutic options, we need to gather the knowledge about the molecular pathogenesis of osteosarcoma and translate them into clinical settings. Both cell intrinsic and environmental factors are undoubtedly and collectively involved in the onset and progression of osteosarcoma as well as the formation of tumor heterogeneity, leading to therapeutic resistance. Genetic and/or epigenetic abnormalities that could dysregulate oncogenes, tumor suppressors and intracellular signaling pathways are frequently observed in osteosarcoma. The complex tumor microenvironment of osteosarcoma including bone homeostasis and the immune response is currently receiving the most attention.
This Special Issue offers an Open Access forum that aims to bring together a collection of original research and review articles addressing the expanding field of the pathogenesis of osteosarcoma. We hope to provide a stimulating resource for the fascinating subject of osteosarcoma research.
Some suggested potential topics are genetic and/or epigenetic disorders, whose study may be based on comprehensive analyses such as genome-wide association studies; genomic instability, which may be caused by chromothripsis and kataegis; molecular disorders that promote tumor heterogeneity and disease progression; the disturbance of bone homeostasis; metabolic abnormalities in osteosarcoma; immunologic findings in osteosarcoma research; and new models for studying osteosarcoma.
Dr. Takatsune Shimizu
Guest Editor
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Keywords
- osteosarcoma
- metastasis tumor heterogeneity
- genomic instability
- cancer metabolism
- bone homeostasis
- tumor immunology