Molecular Role of PARP in Health and Disease 2020
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 27894
Special Issue Editors
Interests: poly(ADP-ribose)polymerase; PARP; mitochondria; sirtuin; metabolism
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Poly(ADP-ribose) polymerases (PARPs or ARTDs) represent a 17-member family characterized by a common catalytic subunit. PARPs use NAD+ as a substrate and PARP1 or PARP2, when activated, can limit NAD+ availability in cells to other enzymes. PARPs and their product, poly(ADP-ribose), regulate transcription and chromatin structure. PARP enzymes have a crucial role in regulating DNA repair making major PARP enzymes attractive targets for pharmacological inhibition. In the past few years, PARP inhibitors have entered clinical use, while at the same time, more specific PARP inhibitors are being developed to target only tankyrases or mono-ADP-ribose polymerases among the PARP family members. In addition to DNA repair and oncological transformation, PARPs influence a plethora of other cellular (patho)physiological processes from metabolism to virus–host interactions.
Prof. Dr. Péter Bay
Dr. Tibor Pankotai
Guest Editors
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Keywords
- PARP
- ARTD
- PARP inhibitors
- PARylation
- MARylation
- macrodomain
- olaparib
- rucaparib
- niraparib chromatin
- transcription
- protein degradation postrranslational modifications
- DNA repair
- cell division
- hetarochromatin tumor
- neoplasia
- cytostatic treatment
- synthetic lethality
- enzyme trapping
- mitochondria
- cell death
- oxidative stress inflammation
- viral infection
- energy sensors
- circadian rhtythm
- metabolic diseases
- aging
Related Special Issue
- Molecular Role of PARP in Health and Disease in Cells (12 articles)