Recent Advances in Tumor Immunological Microenvironment Research

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".

Deadline for manuscript submissions: 15 December 2024 | Viewed by 1899

Special Issue Editor


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Guest Editor
Philips Institute for Oral Health Research, School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
Interests: microenvironmental regulation in cancer progression; novel regulators in tumor responses to immunotherapies; novel signaling pathways controlling tumor growth and metastasis

Special Issue Information

Dear Colleagues,

Over the past decade, cancer immunotherapy has undergone a revolutionary transformation, demonstrating significant clinical potential in modulating immune responses against cancer. This breakthrough offers new hope for the eventual cure of cancer. However, the current response rates among patients undergoing immunotherapies remain suboptimal, highlighting the imperative need to substantially enhance clinical benefits.

The tumor immunological microenvironment plays a pivotal role in shaping the tumor-immune response, and a deeper comprehension of this intricate landscape holds the promise of discovering novel approaches to augment existing immunotherapies.

In this Special Issue, we aim to delve into recent advancements in the field of tumor immunological microenvironment research. The topics under discussion will encompass, but are not limited to:

  • The specific roles of tumor cells, immune cells and stromal cells in shaping the tumor immunological microenvironment;
  • The identification of tumor microenvironment biomarkers capable of predicting responses to immunotherapy;
  • The exploration of innovative animal models and cutting-edge technologies in tumor immunological microenvironment research;
  • Strategies designed to transform the tumor immunological microenvironment from a "cold" state to a "hot" one, rendering it more responsive to immunotherapeutic interventions.

We invite researchers, scientists and clinicians to contribute their insights, studies and findings to this Special Issue.

Best regards,

Dr. Yue Sun
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tumor immune microenvironment
  • cancer immunotherapy
  • immune cells
  • immunosuppression
  • immune cell infiltration

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Published Papers (1 paper)

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Review

37 pages, 1284 KiB  
Review
Intratumoral Microbiome: Foe or Friend in Reshaping the Tumor Microenvironment Landscape?
by Athina A. Kyriazi, Makrina Karaglani, Sofia Agelaki and Stavroula Baritaki
Cells 2024, 13(15), 1279; https://doi.org/10.3390/cells13151279 - 30 Jul 2024
Viewed by 1496
Abstract
The role of the microbiome in cancer and its crosstalk with the tumor microenvironment (TME) has been extensively studied and characterized. An emerging field in the cancer microbiome research is the concept of the intratumoral microbiome, which refers to the microbiome residing within [...] Read more.
The role of the microbiome in cancer and its crosstalk with the tumor microenvironment (TME) has been extensively studied and characterized. An emerging field in the cancer microbiome research is the concept of the intratumoral microbiome, which refers to the microbiome residing within the tumor. This microbiome primarily originates from the local microbiome of the tumor-bearing tissue or from translocating microbiome from distant sites, such as the gut. Despite the increasing number of studies on intratumoral microbiome, it remains unclear whether it is a driver or a bystander of oncogenesis and tumor progression. This review aims to elucidate the intricate role of the intratumoral microbiome in tumor development by exploring its effects on reshaping the multileveled ecosystem in which tumors thrive, the TME. To dissect the complexity and the multitude of layers within the TME, we distinguish six specialized tumor microenvironments, namely, the immune, metabolic, hypoxic, acidic, mechanical and innervated microenvironments. Accordingly, we attempt to decipher the effects of the intratumoral microbiome on each specialized microenvironment and ultimately decode its tumor-promoting or tumor-suppressive impact. Additionally, we portray the intratumoral microbiome as an orchestrator in the tumor milieu, fine-tuning the responses in distinct, specialized microenvironments and remodeling the TME in a multileveled and multifaceted manner. Full article
(This article belongs to the Special Issue Recent Advances in Tumor Immunological Microenvironment Research)
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