Traveling Metalloproteinases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (31 March 2020) | Viewed by 14139

Special Issue Editor


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Guest Editor
Department of Dental Pharmacology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan
Interests: cellular and molecular biology; intercellular communication; extracellular vesicles; tumoroids; organoids; 3D culture systems; gene regulation; non-coding RNA; omics; moonlighting proteins; cancer
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Special Issue Information

Dear Colleagues,

The matrix metalloproteinases (MMP) family were originally found as extracellular proteolytic enzymes which are crucial in diseases, tissue development, angiogenesis, and wound healing. The discovery of intranuclear MMP has been paradigm-shifting in biology and medicine. Moreover, intranuclear MMP alters gene expression at the transcriptional level. Further, recent studies have discovered MMP which is carried by extracellular vesicles such as exosomes, altering the local and distant microenvironment. Therefore, reseachers in the field of the intracellular roles of MMP and vesicle-associated MMP are encouraged to submit original articles and reviews to the journal Cells Special Issue on “Traveling Metalloproteinases”.

Dr. Takanori Eguchi
Guest Editor

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Keywords

  • metalloproteinase
  • gene regulation, transcription
  • cancer
  • angiogenesis
  • immunology, inflammation
  • wound healing
  • vesicle traffic

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Published Papers (1 paper)

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Review

18 pages, 5034 KiB  
Review
Structure and Function of Human Matrix Metalloproteinases
by Helena Laronha and Jorge Caldeira
Cells 2020, 9(5), 1076; https://doi.org/10.3390/cells9051076 - 26 Apr 2020
Cited by 313 | Viewed by 13716
Abstract
The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and [...] Read more.
The extracellular matrix (ECM) is a macromolecules network, in which the most abundant molecule is collagen. This protein in triple helical conformation is highly resistant to proteinases degradation, the only enzymes capable of degrading the collagen are matrix metalloproteinases (MMPs). This resistance and maintenance of collagen, and consequently of ECM, is involved in several biological processes and it must be strictly regulated by endogenous inhibitors (TIMPs). The deregulation of MMPs activity leads to development of numerous diseases. This review shows MMPs complexity. Full article
(This article belongs to the Special Issue Traveling Metalloproteinases)
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