RAS Proteins and Tumorigenesis
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (15 October 2023) | Viewed by 132
Special Issue Editor
2. Harvard Medical School, Boston, MA, USA
Interests: Rho signaling in epithelial morphogenesis and oncogenic transformation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
RAS proteins are small GTPases that act as molecular switches and play a vital role in intracellular signaling pathways for cell proliferation, differentiation, and survival. Mutations in RAS genes are common in many cancers, causing constitutive activation of downstream signaling pathways, such as MAPK/ERK and PI3K/AKT/mTOR. This persistent activation contributes to tumorigenesis, promoting cell proliferation, survival, metastasis, and altering cellular metabolism, DNA damage repair, immune evasion, and angiogenesis. Despite challenges in developing targeted therapies, recent advances in understanding RAS biology have led to novel therapeutic approaches, including direct targeting of mutant RAS proteins, inhibiting downstream signaling pathways, and modulating the tumor microenvironment. In addition, therapies are evolving for proteins that engage in cross-talk with constituents of canonical RAS signaling pathways. For this issue, we welcome contributions on genes and encoded proteins of the RAS pathway 2.0 as defined by Frank McCormick, including the lesser studied constituents.
Dr. Steen H. Hansen
Guest Editor
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Keywords
- RAS proteins
- GTPases
- tumorigenesis
- cellular metabolism
- tumor microenvironment
- downstream signaling pathways
