DOCK Proteins in Mammalian Physiology and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 2453
Special Issue Editor
2. Harvard Medical School, Boston, MA, USA
Interests: Rho signaling in epithelial morphogenesis and oncogenic transformation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Ras superfamily of GTP-binding proteins influences a very wide range of developmental, homeostatic and pathobiological processes in mammals and lower organisms. The activation of most Ras-like proteins is potently facilitated by guanine nucleotide exchange factors (GEFs) which promote exchange of GDP for GTP. The Ras superfamily consists of the Arf, Ran, Rab, Ras, and Rho branches. For the Rho branch, two structurally highly distinct classes of GEFs exist: Dbl (diffuse B-cell lymphoma) and DOCK (dedicator of cytokinesis). Initially, Dbl proteins received much attention for the simple reason that they were discovered earlier than DOCKs. However, DOCK proteins have since taken on substantial importance. DOCKs serve as GEFs for the Cdc42 and Rac GTPases and comprise a total of 11 members divided into four subfamilies, A–D, based on structural similarity and substrate preference.
This upcoming Special Issue of Cells will provide an overview of the profound impact that individual DOCKs exert on mammalian physiology and disease.
Dr. Steen H. Hansen
Guest Editor
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Keywords
- Cdc42
- Dbl
- DOCK
- GEF
- Rac
- Rho
