The Cell Biology of Inositol
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 25 February 2025 | Viewed by 60
Special Issue Editors
Interests: inositol in endocrine control and carcinogenesis; tumor reversion through epigenetic and microenvironment modification; biophysical control of morphogenesis and differentiation
Special Issues, Collections and Topics in MDPI journals
2. EGOI (The Experts Group on Inositol in Basic and Clinical Research and PCOS), Rome, Italy
Interests: inositol in endocrine control and polycystic ovary syndrome; inositol in gynecological diseases; inositol and steroid control in ovary and oocyte development
Special Issue Information
Dear Colleagues,
Inositol (myo-inositol) plays a critical role in several physiological pathways, and increasing evidence points out that it is involved in several pathological conditions, alongside with its main isomers (scyllo- and D-chiro-inositol). Myo-inositol is at the root of many secondary derivatives— inositol phosphates, phosphoinositides, and pyrophosphates—produced through a branched metabolism that spreads across many pathways. Despite the impressive body of studies released in the past thirty years, we are still missing the full appraisal regarding some critical aspects of inositol physiology. What is the fate of myo-inositol picked up by cells? How is the endogenous myo-inositol synthesis during specific conditions regulated (inositol starvation, inositol addition, cancer growth, morphogenesis, etc.)? Does endogenous inositol take a different intracellular pathway with respect to the exogenous poliol? Does inositol undergo a different metabolism in cancerous cells? Could inositol interfere with endocrine control either by itself or through secondary derivatives? Moreover, since its inclusion within the membranes of eukaryotic cells, inositol and its derivatives seem to play a unique role in mediating the crosstalk among the cells and their microenvironment, representing an important constituent of the bio-dynamical interface. Therefore, it is not surprising that de-regulation of inositol metabolism could viewed as a significant player during several illnesses, including cancer, endocrine disorders, neurological disorders, and metabolic diseases.
Relevant topics:
- Assessment of the nutritional status of inositol: dietary requirements in health, development, and disease;
- Analytical strategies in assessing inositol (and metabolites) status in organic fluids and tissues;
- Inositol(s) and phosphate derivatives in cell membranes and organelles;
- Intracellular metabolism of myo-inositol;
- Myo-inositol and cell metabolism: focus on insulin signaling;
- Inositol(s) in endocrine control of steroidogenesis;
- Inositol(s) and neurodegenerative diseases;
- Inositol(s) and cancer.
Dr. Mariano Bizzarri
Dr. Simona Dinicola
Guest Editors
Manuscript Submission Information
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Keywords
- inositol
- organic fluids and tissues
- cell membranes and organelles
- cell metabolism
- nutrition
- neurodegenerative diseases
- cancer
- inositol pyrophosphates
- inositol phosphates and phosphoinositides
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