Precision Medicine to Profile Cancer through Circulating Tumor DNA: Clinical Applications and Future Perspectives

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell and Gene Therapy".

Deadline for manuscript submissions: closed (30 November 2019) | Viewed by 6579

Special Issue Editor


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Department of Medical, Surgery and Health Sciences, University of Trieste, Piazza Ospitale 1, 34129 Trieste, Italy
Interests: breast cancer; molecular oncology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A new methodology is being developed that relies on circulating tumor DNA (ctDNA). ctDNA is released into the blood stream when cells die. From time to time, cancer cells die from while a tumor is growing. ctDNA can be detected by drawing the blood plasma from patients during treatment or during the cancer staging process. Explosive advances in the field of cancer research have given rise to an array of mutated DNA sequences indicative of cancer cells. Testing blood plasma for cancer-specific DNA sequences represents the frontier of cancer diagnostics and treatment selection. Topics for this Special Issue include the following:

  • Editorial: Utility of circulating tumor DNA for personalized cancer therapy;
  • Circulating tumor DNA for drug selection and dynamic monitoring in advanced non-small cell lung cancer;
  • Circulating tumor DNA for the management of anti-EGFR therapy in colorectal cancer;
  • Circulating tumor DNA in advanced breast cancer: a new tool for drug selection;
  • Circulating tumor DNA and the treatment of castration-resistant prostate cancer;
  • Circulating tumor DNA: a new potential diagnostic approach for the big killers.

Prof. Daniele Generali
Guest Editor

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Keywords

  • breast cancer
  • prostate cancer
  • colon cancer
  • lung cancer
  • rare cancer
  • circulating tumor DNA
  • precision medicine
  • personalized cancer therapy
  • drug selection and monitoring

Published Papers (1 paper)

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Review

30 pages, 1346 KiB  
Review
Translational Application of Circulating DNA in Oncology: Review of the Last Decades Achievements
by Natalia O. Tuaeva, Luca Falzone, Yuri B. Porozov, Alexander E. Nosyrev, Vladimir M. Trukhan, Leda Kovatsi, Demetrios A. Spandidos, Nikolaos Drakoulis, Alexandra Kalogeraki, Charalampos Mamoulakis, George Tzanakakis, Massimo Libra and Aristides Tsatsakis
Cells 2019, 8(10), 1251; https://doi.org/10.3390/cells8101251 - 14 Oct 2019
Cited by 54 | Viewed by 6226
Abstract
In recent years, the introduction of new molecular techniques in experimental and clinical settings has allowed researchers and clinicians to propose circulating-tumor DNA (ctDNA) analysis and liquid biopsy as novel promising strategies for the early diagnosis of cancer and for the definition of [...] Read more.
In recent years, the introduction of new molecular techniques in experimental and clinical settings has allowed researchers and clinicians to propose circulating-tumor DNA (ctDNA) analysis and liquid biopsy as novel promising strategies for the early diagnosis of cancer and for the definition of patients’ prognosis. It was widely demonstrated that through the non-invasive analysis of ctDNA, it is possible to identify and characterize the mutational status of tumors while avoiding invasive diagnostic strategies. Although a number of studies on ctDNA in patients’ samples significantly contributed to the improvement of oncology practice, some investigations generated conflicting data about the diagnostic and prognostic significance of ctDNA. Hence, to highlight the relevant achievements obtained so far in this field, a clearer description of the current methodologies used, as well as the obtained results, are strongly needed. On these bases, this review discusses the most relevant studies on ctDNA analysis in cancer, as well as the future directions and applications of liquid biopsy. In particular, special attention was paid to the early diagnosis of primary cancer, to the diagnosis of tumors with an unknown primary location, and finally to the prognosis of cancer patients. Furthermore, the current limitations of ctDNA-based approaches and possible strategies to overcome these limitations are presented. Full article
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