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Cells
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Fungi: Genomics, Cell Biology and Molecular Mechanisms of Interactions
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Fungi: Genomics, Cell Biology and Molecular Mechanisms of Interactions

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Plant, Algae and Fungi Cell Biology".

Deadline for manuscript submissions: closed (10 March 2022) | Viewed by 4956

Special Issue Editors

Prof. Dr. N. Louise Glass

E-Mail Website
Guest Editor
1. Plant and Microbial Biology Department, The University of California, Berkeley, CA 94720, USA
2. Division of Environmental Genomics and Systems Biology, The Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Interests: fungal genetics; fungal genomics; regulatory networks; nutrient acquisition; allorecognition; programmed cell death; fungal innate immunity
Dr. Chang-hyun Khang

E-Mail Website
Guest Editor
Department of Plant Biology, The University of Georgia, Athens, GA 30602, USA
Interests: fungal cell and molecular genetics; nuclear division and migration; fungal effector gene regulation and protein trafficking; fungal–plant interactions with emphasis on rice blast; fungal pathogenicity and plant immunity

Special Issue Information

Dear Colleagues,

Recent advances in genomics, CRISPR and microscopic technology have allowed the interrogation of fungal biology and the exploration of interactions of fungi with each other and with other organisms in their environment, both antagonistic and beneficial.  In this Special Issue of Cells, we invite fungal biologists to submit their original research articles, reviews, or shorter perspective articles on all aspects related to genetics, epigenetics, genomics, molecular and cellular mechanisms that elucidate aspects of fungal biology or interactions of fungi with other organisms. Articles with insights from a cell biology and molecular biological perspective are especially welcome.

Prof. Dr. N. Louise Glass
Dr. Chang-hyun Khang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungi
  • host–fungal interactions
  • pathogenesis
  • ecology
  • genomics
  • population genomics
  • symbiosis

Published Papers (2 papers)

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Research

13 pages, 11734 KiB  
Article
Overexpression of MET4 Leads to the Upregulation of Stress-Related Genes and Enhanced Sulfite Tolerance in Saccharomyces uvarum
by Zhuo Wei, Zhiming Zhang, Wenjuan Zhao, Tuo Yin, Xiaozhen Liu and Hanyao Zhang
Cells 2022, 11(4), 636; https://doi.org/10.3390/cells11040636 - 11 Feb 2022
Cited by 5 | Viewed by 1979
Abstract
Saccharomyces uvarum is one of the few fermentative species that can be used in winemaking, but its weak sulfite tolerance is the main reason for its further use. Previous studies have shown that the expression of the methionine synthase gene (MET4) [...] Read more.
Saccharomyces uvarum is one of the few fermentative species that can be used in winemaking, but its weak sulfite tolerance is the main reason for its further use. Previous studies have shown that the expression of the methionine synthase gene (MET4) is upregulated in FZF1 (a gene encoding a putative zinc finger protein, which is a positive regulator of the transcription of the cytosolic sulfotransferase gene SSU1) overexpression transformant strains, but its exact function is unknown. To gain insight into the function of the MET4 gene, in this study, a MET4 overexpression vector was constructed and transformed into S. uvarum strain A9. The MET4 transformants showed a 20 mM increase in sulfite tolerance compared to the starting strain. Ninety-two differential genes were found in the transcriptome of A9-MET4 compared to the A9 strain, of which 90 were upregulated, and two were downregulated. The results of RT-qPCR analyses confirmed that the expression of the HOMoserine requiring gene (HOM3) in the sulfate assimilation pathway and some fermentation-stress-related genes were upregulated in the transformants. The overexpression of the MET4 gene resulted in a significant increase in sulfite tolerance, the upregulation of fermentation-stress-related gene expression, and significant changes in the transcriptome profile of the S. uvarum strain. Full article
(This article belongs to the Special Issue Fungi: Genomics, Cell Biology and Molecular Mechanisms of Interactions)
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13 pages, 1765 KiB  
Communication
Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance Response
by Xuejiao Jin, Huihui Zhao, Min Zhou, Jie Zhang, Tingting An, Wenhao Fu, Danqi Li, Xiuling Cao and Beidong Liu
Cells 2021, 10(12), 3512; https://doi.org/10.3390/cells10123512 - 13 Dec 2021
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Abstract
Sodium metabisulfite (Na2S2O5) is widely used as a preservative in the food and wine industry. However, it causes varying degrees of cellular damage to organisms. In order to improve our knowledge regarding its cyto-toxicity, a genome-wide screen [...] Read more.
Sodium metabisulfite (Na2S2O5) is widely used as a preservative in the food and wine industry. However, it causes varying degrees of cellular damage to organisms. In order to improve our knowledge regarding its cyto-toxicity, a genome-wide screen using the yeast single deletion collection was performed. Additionally, a total of 162 Na2S2O5-sensitive strains and 16 Na2S2O5-tolerant strains were identified. Among the 162 Na2S2O5 tolerance-related genes, the retromer complex was the top enriched cellular component. Further analysis demonstrated that retromer complex deletion leads to increased sensitivity to Na2S2O5, and that Na2S2O5 can induce mislocalization of retromer complex proteins. Notably, phosphatidylinositol 3-monophosphate kinase (PI3K) complex II, which is important for retromer recruitment to the endosome, might be a potential regulator mediating retromer localization and the yeast Na2S2O5 tolerance response. Na2S2O5 can decrease the protein expressions of Vps34, which is the component of PI3K complex. Therefore, Na2S2O5-mediated retromer redistribution might be caused by the effects of decreased Vps34 expression levels. Moreover, both pharmaceutical inhibition of Vps34 functions and deletions of PI3K complex II-related genes affect cell tolerance to Na2S2O5. The results of our study provide a global picture of cellular components required for Na2S2O5 tolerance and advance our understanding concerning Na2S2O5-induced cytotoxicity effects. Full article
(This article belongs to the Special Issue Fungi: Genomics, Cell Biology and Molecular Mechanisms of Interactions)
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