Glycosylation and Cell Biology
A topical collection in Cells (ISSN 2073-4409).
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Interests: mucin-type O-glycosylation; O-glycoproteins; mucins; MUC1; cancer; innate immunity; galactosemia; glycomics; (glyco)proteomics; mass spectrometry
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Topical Collection Information
Dear Colleagues,
The complex interplay of sugar metabolism and protein glycosylation (evident in a series of congenital disorders) and the impact of protein dys-glycosylation on protein sorting for targeted transport and targeted protein transport to plasma membranes are currently attracting researchers’ attention. These challenging topics are related to cellular functions at higher organizational levels, such as receptor-mediated cell signaling (for example, glycosylation can be a main regulator of growth and death factor receptors’ signaling) and associated molecular pathomechanisms. A series of questions could be addressed; for instance: How is cell signaling modulated by receptor glycosylation? How is it regulated, by direct effects on protein structure (see VEGFR in endothelial cells) or by indirect effects, like altered raft sorting? What is the molecular basis of glycosylation-dependent effects on protein sorting for targeted transport to their subcellular destinations?
Another topic of high research actuality refers to rare O-glycosylation types and their regulatory influence on cellular pathways (O-GlcNAc), on cell–cell interactions (O-mannosylation of cadherins) and cell–matrix interactions, mediated by O-mannosylated lecticans in the perineural net. What is the functional implication of glycans exhibiting the protein-specific, peripheral sugar modulation LacdiNAc (e.g., in self-renewal of embryonic stem cells by regulating LIF/STAT3 signaling)?
There are many more open questions related to complex glycosylation of proteins and its functional impact at the molecular and cellular levels which could be addressed in this Topical Collection, which is designed as a platform for featuring the most recent original work on these topics together with high-standard surveys.
Prof. Franz-Georg Hanisch
Collection Editor
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Keywords
- cell signaling
- trafficking (targeted transport)
- lipid rafts
- extracellular matrix
- glycoproteome
- glycomics
- N/O-glycosylation
- rare O-glycosylation