Cancer Stem Cells and Radiation Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Biophysics".
Deadline for manuscript submissions: closed (25 March 2022) | Viewed by 4275
Special Issue Editor
Special Issue Information
Dear Colleagues,
Growing evidence supports the hierarchical organization of solid cancer with a small population of cancer stem cells/cancer-initiating cells at the apex of this hierarchy, able to regrow a tumor after sublethal treatment and to produce more differentiated progeny. The heterogeneity of cancers and the cancer stem cell hypothesis are a century-old concept in oncology that has been taken into consideration in radiation biology and radiotherapy for decades. Radiotherapy is and will remain a main pillar of clinical cancer treatment in the foreseeable future, and radiation is the most precisely administered ‘drug’ against cancer, and the one we continue to know the most about. Nevertheless, the radiobiology of cancer stem cells/cancer-initiating cells is less developed. In recent years, novel marker systems and culturing techniques that enrich cancer cells have taken radiobiology research on tumor-initiating cells to the next level.
It is becoming increasingly clear that the heterogeneity of cancer cells is not restricted to differences in tumorgenicity but also extends to their response to genotoxic stress, interaction with the tumor microenvironment, and targeted therapies in combined modality regimens. The purpose of this Special Issue is to summarize our current state of knowledge on the radiation biology of cancer stem/cancer-initiating cells in solid cancers, experimental methods, and gold standards to assess cancer stem cell/tumor-initiating cell traits at the functional level in vitro and in vivo and to highlight recent developments in the field to improve the efficacy of radiotherapy against cancer stem/cancer-initiating cells.
Prof. Dr. Frank Pajonk
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
