Glioblastoma Cell: From Molecular Target to Innovative Therapy
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (25 March 2022) | Viewed by 39058
Special Issue Editor
Interests: cancer biology; glioma; cell biology; cell adhesion; pharmacology; neuro-oncology; natural adjuvant therapy; astrocytoma
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gliomas are the most malignant and aggressive form of brain tumors and account for the majority of brain cancer-related deaths. Malignant gliomas are treated with chemo (temozolomide) and radiotherapy, with only a slight benefit in survival time. Numerous advances have been made in understanding the biology of gliomas, including the discovery of cancer stem cells, called glioma stem cells (GSCs), likely responsible of tumor recurrence. Several molecular markers have been proposed as predictors for the prognosis of patients with glioblastoma: some of the best-known molecular markers (IDH, EGFR, p53, PI3K, Rb and RAF), have considerable clinical relevance. In the context of the molecular characterization of brain tumors, the diagnosis of methylation of the MGMT gene is of particular clinical interest. The new WHO classification 2016 supplemented the morphological classification with molecular changes (IDH1 mutations, 1p / 19q loss, MGMT methylation). This special issue will cover all aspects of glioblastoma cell growth, including the study of the mechanisms underlying growth inhibition: apoptosis, autophagy, necrosis. Studies on new adjuvant substances for the treatment of glioblastoma, advanced personalized molecular diagnosis and response to novel molecular targeted therapy will be promising. Along with original research articles of in vitro and in vivo models of glioblastoma, comprehensive and up-to-date reviews of these topics are encouraged to summarize and understand the current state and future directions of glioblastoma cell biology and therapy.
Dr. Antonella Arcella
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Glioblastoma cell line
- adjuvant substance
- target therapy
- molecular pathways
- molecular markers
- GSCs
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.