The Role of microRNAs in the Regulation of Adipose Tissue Functionality
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 6827
Special Issue Editor
Interests: obesity; type 2 diabetes; adipose tissue; browning; angiogenesis; cell biology; animal physiology; hypertension; metabolism; insulin resistance; human physiology; nutrition; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The prevalence of obesity has increased dramatically in recent decades and it is now considered a non-infectious pandemic in the 21st century. Obesity has been shown to decrease life expectancy and has been found to be associated with type 2 diabetes, insulin resistance, mental disorders, certain cancers, and cardiovascular diseases. Previous studies have reported that adipose tissue dysfunction might link obesity to insulin resistance and type 2 diabetes development. Thus, adipose tissue expandability may be an important factor determining obesity-associated comorbidities. The existence of discordant phenotypes, such as subjects with obesity without metabolic complications or diabetic lean individuals, has been explained by the limit of the functional capacity of adipose tissue. When this capacity is exceeded, metabolic disorders occur. MicroRNAs (miRNAs) are involved in the development and function of AT and have been suggested as promising therapeutic targets in managing obesity. In fact, miRNAs have gained considerable attention not only for their ability to regulate adipogenesis and adipose tissue function, but also for their extracellular presence, such as in circulating blood or urine, raising their potential use as biomarkers for diagnosis or prognosis. Although there is growing evidence for an important role of miRNAs in regulating the pathways in adipose tissue that control a range of processes including adipogenesis, insulin resistance and inflammation, more knowledge is needed to investigate the potential regulatory mechanisms that miRNAs could play in AT regulation.
Dr. Rajaa El Bekay
Guest Editor
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Keywords
- obesity
- type 2 diabetes
- insulin resistance
- cardiovascular disease
- cancer
- adipose tissue
- miRNAs
