Microtubules in Nervous System Function
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: closed (15 December 2021)
Special Issue Editor
Special Issue Information
Dear Colleagues,
In neurons of the central nervous system, microtubules play important roles in shaping dendritic and axonal arbors, regulating cellular migration, and maintaining general function. Additionally, they serve as structures for the transport of proteins to the synapse and use molecular motors to specify which cargo they transport. Transient changes to microtubules in dendritic spines occur after long-term potentiation, and these changes are thought to be essential for learning and memory. Degradation of microtubules occurs in response to neuronal injury, and in neurodegenerative disease, disorganization of microtubules can occur.
A recent focus in the field includes the study of posttranslational modifications and the binding of microtubule-associated proteins to microtubules and how these influence development and function. Microtubules are also composed of different tubulin isotypes, and combined with post-translational modifications, these alterations are termed the “tubulin code”. Changes to the tubulin code affect how the microtubules shape the development and function of the nervous system.
In this Special Issue, we will include papers that address the role that microtubules play in the nervous system, from the single cell level to the organism.
Prof. Dr. Bonnie Firestein
Guest Editor
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Keywords
- neurons
- nervous system
- microtubules
- cytoskeleton
- post-translational modification
- tubulin code
- microtubule-binding proteins
- nervous system development
- neurodegeneration
- molecular cargo
- microtubule motors
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